Episode archive

Posted on June 13th 2024 (5 days)

Apolipoprotein B, or ApoB for short, is a structural protein found in LDL particles. If ApoB gets oxidized or modified, it can drive the formation...

Posted on June 13th 2024 (6 days)

Dr. Rhonda Patrick discusses fish oil and Afib risk, hyperbaric oxygen therapy, supplements for kids, and curcumin's impact on testosterone.

Posted on June 10th 2024 (8 days)

Dr. Andrew Huberman discusses the role of dopamine in driving motivation and offers practical tools for enhancing mood and focus.

Posted on May 31st 2024 (18 days)

Dr. Rhonda Patrick discusses resistant starch, red light therapy risks, stem cells, and the link between benzodiazepines and dementia in her latest Q&A session.

Posted on May 27th 2024 (22 days)

Dr. Levine details his research findings that show how a structured exercise regimen can reverse up to 20 years of heart aging.

Posted on May 9th 2024 (about 1 month)

Living long, healthy lives isn't just about luck; it's about putting in the effort and staying committed. There's plenty of scientific evidence out there tha...

Posted on May 3rd 2024 (about 2 months)

I've interviewed many scientists over the years, each with their own expertise and specialty, ranging from exercise science and kinesiology to gene editing a...

Posted on April 16th 2024 (2 months)

Vitamins are substances that our bodies need to develop and function normally. When considering vitamins, we tend to think of the usual suspects – A, C, D, E...

Posted on April 15th 2024 (2 months)

Dr. Rhonda Patrick explores collagen peptides, high-dose niacin and vitamin B6, avoiding nano- and microplastics in her latest Q&A.

Posted on April 11th 2024 (2 months)

Roughly half of adults in the US have hypertension, commonly known as high blood pressure. Defined as having a systolic pressure of 130 or higher or a diasto...

Posted on April 4th 2024 (3 months)

This is my keynote presentation from the 2024 CrossFit Health Summit where I explored how vigorous exercise and heat stress contribute to longevity.

Posted on March 26th 2024 (3 months)

Adequate, quality sleep is essential for the body's recovery and repair, promoting optimal physical and mental health. Getting a good night's sleep can be ch...

Posted on March 19th 2024 (3 months)

Dr. Rhonda Patrick explores blood tests to track health, statin alternatives, mitochondrial supplements, and vitamin B12 and autism risk in her latest Q&A.

Posted on March 15th 2024 (3 months)

In this solo episode, I'm taking an in-depth look at magnesium – a critical yet frequently underestimated mineral in our health.

Posted on March 11th 2024 (3 months)

In part I of this two-part series on the future of aging research, we discussed the hallmarks of aging and the cutting-edge therapies aimed at understanding ...

Posted on February 21st 2024 (4 months)

In my keynote at LongevityFest 2023, I share powerful habits to delay aging and improve healthspan, presented at the American Academy of Anti-Aging Medicine.

Posted on February 16th 2024 (4 months)

Dr. Rhonda Patrick explores creatine, dairy's effect on polyphenols, eggs' health impact, and new weight loss drugs like Ozempic in her latest Q&A.

Posted on February 12th 2024 (4 months)

Researchers in the field of aging science have identified nine hallmarks of aging – observable biological patterns of dysfunction that occur as an organism a...

Posted on January 26th 2024 (5 months)

Muscle disuse atrophy, or muscle wasting, poses serious risks, particularly for older adults, promoting irreversible muscle loss, frailty, and disease. Rebui...

Posted on January 15th 2024 (5 months)

Dr. Rhonda Patrick explores iodine supplementation, choline & TMAO, curcumin safety, and red yeast rice in her latest Q&A.

Posted on January 8th 2024 (5 months)

From preconception to toddlerhood and early childhood, there's a lot to consider when deciding to have a baby. Dr. Rhonda Patrick spent many months researchi...

Posted on December 27th 2023 (6 months)

Dr. Peter Attia presents practical steps we can implement to improve our health, emphasizing the importance of each aspect while providing actionable advice.

Posted on December 11th 2023 (6 months)

Dr. Rhonda Patrick explores melatonin's antioxidant properties, curcumin supplementation, antinutrients, and SARMs in her latest Q&A.

Posted on December 4th 2023 (7 months)

Time-restricted eating involves consuming meals within a specific daily time window. However, choosing the optimal time frame for that window is influenced b...

Posted on December 1st 2023 (7 months)

This episode, featuring Dr. Rhonda Patrick, dives deep into the science and practicality of incorporating vigorous-intensity exercise into our lives.

Posted on November 22nd 2023 (7 months)

Time-restricted eating involves consuming meals within a specific daily time window but is distinct from true fasting, which involves extended food abstinenc...

Posted on November 9th 2023 (7 months)

Dr. Rhonda Patrick explores cheese's health impact, ergothioneine's longevity properties, sleep and joint supplements, and red light therapy in her latest Q&A.

Posted on November 8th 2023 (7 months)

Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Cold exposure, a powerful hormetic stressor, act...

Posted on November 8th 2023 (7 months)

Dr. Rhonda Patrick describes strategies you can apply immediately to enhance your health and prevent chronic disease.

Posted on October 22nd 2023 (8 months)

Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Heat exposure – from sauna use, hot tubs, or eve...

Posted on October 11th 2023 (8 months)

Dr. Rhonda Patrick explores supplemental tyrosine, lion's mane, cordyceps, aging tests, and sunscreen's efficacy and safety in a Q&A.

Posted on October 3rd 2023 (9 months)

As research progresses, my dietary and supplement habits adapt. At times, it's the ineffable quality of consciousness, submerged in a mental calculus of cost...

Posted on September 19th 2023 (9 months)

Dr. Martin Gibala discusses HIIT's health benefits and describes common HIIT protocols.

Posted on September 7th 2023 (10 months)

Dr. Rhonda Patrick discusses concerns about early smartphone and tablet access among kids and its effects on mental health later in life.

Posted on September 7th 2023 (10 months)

Dr. Rhonda Patrick explores growth hormone secretagogues, spermidine's longevity role, methylene blue, whey protein, and solutions for scar tissue in a Q&A.

Posted on August 27th 2023 (10 months)

Sulforaphane, a bioactive compound derived from broccoli, broccoli sprouts, and red kale, exerts potent antioxidant and anti-inflammatory properties that can...

Posted on August 13th 2023 (10 months)

Dr. Rhonda Patrick explores taurine's longevity role, cocoa flavanols, training adaptations, and oral hyaluronic acid in a Q&A.

Posted on August 11th 2023 (10 months)

Berberine is a plant-derived compound that may be beneficial for treating a wide range of chronic health conditions associated with obesity, such as hyperten...

Posted on July 28th 2023 (11 months)

Having a healthy body composition, with plenty of lean mass – in the form of muscle and bones – is essential for health throughout the lifespan. Achieving a ...

Posted on July 11th 2023 (11 months)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 3rd 2023 (12 months)

Dr. Chris McGlory discusses muscle protein dynamics, emphasizing how omega-3 helps maintain muscle mass in older adults.

Posted on June 29th 2023 (12 months)

The blood-brain barrier is a collection of membranes that separate the central nervous system from the circulatory system. It permits the passage of nutrient...

Posted on June 13th 2023 (about 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on June 4th 2023 (about 1 year)

It's tempting to think of dementia as something in the long-distant future – a condition that only affects older people. But the factors that drive dementia ...

Posted on May 30th 2023 (about 1 year)

Heat therapy (saunas, exercise, hot baths) can enhance slow-wave sleep. This video explores exercise and heat's joint role in sleep regulation.

Posted on May 24th 2023 (about 1 year)

Vascular dysfunction, the loss of normal endothelial tone and permeability of blood vessels, is a common feature of most forms of dementia, including Alzheim...

Posted on May 17th 2023 (about 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on May 5th 2023 (about 1 year)

A ketogenic diet is high in fat, moderate in protein, and low in carbohydrates. Research shows that it mimics fasting by inducing metabolic switching – the c...

Posted on April 29th 2023 (about 1 year)

Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body dur...

Posted on April 23rd 2023 (about 1 year)

Photobiomodulation (PBM) involves using light therapy, such as red light, laser, or infrared therapy, to stimulate, heal, regenerate, and protect the body. F...

Posted on April 16th 2023 (about 1 year)

Your skin is a crucial barrier to the outside world – the first line of defense against environmental exposures, and the primary means by which the body reta...

Posted on April 1st 2023 (about 1 year)

Chronic inflammation plays a key role in the development of many chronic diseases, including cancer, cardiovascular disease, and diabetes. When it comes to m...

Posted on April 1st 2023 (about 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on March 24th 2023 (about 1 year)

Bone density is crucial throughout the lifespan, but it takes on even greater importance as we age, as bone mass really begins to decline. Resistance trainin...

Posted on March 23rd 2023 (about 1 year)

APOE is a protein involved in lipid transport. A variant of APOE called APOE4 is the primary genetic risk factor for Alzheimer's disease. APOE4 also increase...

Posted on March 4th 2023 (over 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on February 27th 2023 (over 1 year)

Dr. Axel Montagne discusses blood-brain barrier dysfunction in dementia and early-stage age-related cognitive decline.

Posted on February 20th 2023 (over 1 year)

Apolipoprotein B, or ApoB for short, is a protein involved in lipid metabolism and is a robust predictor of cardiovascular disease risk. Healthy lifestyle be...

Posted on February 4th 2023 (over 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on January 25th 2023 (over 1 year)

Protein is an essential component of a healthy eating pattern because it supports the growth, development, and maintenance of skeletal muscle. While animal-d...

Posted on January 18th 2023 (over 1 year)

Although people experience muscle soreness to varying degrees, soreness is perfectly normal after training and typically occurs following exposure to novel s...

Posted on January 7th 2023 (over 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on January 6th 2023 (over 1 year)

Incorporating resistance training into your exercise regimen presents a scheduling dilemma – there's simply not enough time. Performing time-efficient workou...

Posted on January 4th 2023 (over 1 year)

Migraine is a neurological disorder that typically manifests as an intense, debilitating headache and is often accompanied by nausea, vomiting, and light sen...

Posted on December 28th 2022 (over 1 year)

Meditation, in its various forms, has powerful effects on the brain and body. In this second part of our two-part series on meditation, we'll discuss some of...

Posted on December 25th 2022 (over 1 year)

Meditation is a form of mental training geared toward improving aspects of a person's core neurocognitive function, such as the regulation of attention and e...

Posted on December 6th 2022 (over 1 year)

Dr. Brad Schoenfeld studies the importance of resistance exercise in maintaining muscle mass.

Posted on December 3rd 2022 (over 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 28th 2022 (over 1 year)

Protein is essential for building and maintaining muscles. Aiming for about 1.2 to 1.6 grams of protein per kilogram of body weight (about 0.5 to 0.7 grams p...

Posted on November 22nd 2022 (over 1 year)

Consuming sufficient protein is essential for muscle growth and maintenance. Emphasis on specific amino acids within protein, particularly the branched-chain...

Posted on November 12th 2022 (over 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 6th 2022 (over 1 year)

Exercise stresses the entire body – the heart, lungs, bones, muscles, and even the brain. The body responds by inducing a wide range of adaptations that incr...

Posted on November 2nd 2022 (over 1 year)

When people exercise as part of a treatment for alcohol abuse disorder it reduces their volume of alcohol consumption. But why? One reason may be FGF21.

Posted on October 26th 2022 (over 1 year)

Protein is an essential component of a healthy eating pattern because it supports the growth, development, and maintenance of skeletal muscle tissue. Having ...

Posted on October 20th 2022 (over 1 year)

The progressive loss of skeletal muscle mass and strength that occurs with aging, referred to as sarcopenia, begins as early as our 30s or 40s. Many factors ...

Posted on October 15th 2022 (over 1 year)

High-intensity interval training, or HIIT for short, is a popular form of exercise involving short bursts of intense aerobic exercise interspersed with perio...

Posted on October 1st 2022 (over 1 year)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on September 30th 2022 (over 1 year)

Exposure to environmental toxins – in the food we eat, the water we drink, and the air we breathe – is largely unavoidable. But monitoring our exposures and ...

Posted on September 22nd 2022 (over 1 year)

Choline is an essential nutrient that plays important roles in human health. It provides methyl groups for many aspects of metabolism, is a component of cell...

Posted on September 15th 2022 (almost 2 years)

Sugar substitutes are food products or additives that provide the sweet taste of sugar, without the calories. Evidence suggests that sugar substitutes have s...

Posted on September 3rd 2022 (almost 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on August 31st 2022 (almost 2 years)

Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, ...

Posted on August 23rd 2022 (almost 2 years)

Dr. George Church discusses revolutionary technologies in the field of genetic engineering.

Posted on August 6th 2022 (almost 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on August 2nd 2022 (almost 2 years)

Chocolate and its principal component, cocoa, are popular topics – no doubt because they taste so good. But a wide range of beneficial health effects have be...

Posted on July 27th 2022 (almost 2 years)

Continuous glucose monitors – CGMs, for short – are wearable devices that measure blood glucose levels through a tiny sensor placed under the skin. The CGM c...

Posted on July 21st 2022 (almost 2 years)

Vitamin K is a type of fat-soluble vitamin that participates in blood clotting, cardiovascular health, and bone metabolism. Naturally occurring forms of vita...

Posted on July 20th 2022 (almost 2 years)

Lifestyle factors and new technologies offer the promise of living longer, healthier lives, but is there a limit to the human lifespan? This episode explores the different theories supporting this hotly debated topic.

Posted on July 9th 2022 (almost 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 5th 2022 (almost 2 years)

Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasin...

Posted on June 29th 2022 (almost 2 years)

Dr. Stuart Phillips discusses how exercise and nutrition influence skeletal muscle-protein turnover and muscle maintenance throughout the lifespan.

Posted on June 21st 2022 (almost 2 years)

Meat – especially red meat – is perhaps one of the most polarizing topics in the nutrition world today. Some camps tout the benefits of eating an all-meat di...

Posted on June 15th 2022 (about 2 years)

While some research suggests drinking alcohol improves health, an abundance of evidence indicates that drinking alcohol also harms health. Particularly, high...

Posted on June 4th 2022 (about 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on May 30th 2022 (about 2 years)

Dr. Patrick's keynote: compromised intestinal barrier affects human health—cardiometabolic function, neurological health, behavior, and more.

Posted on May 27th 2022 (about 2 years)

The Mediterranean diet pattern is rich in micronutrient-dense foods such as vegetables, fish, and olive oil and has been shown to reduce the risk of cardiova...

Posted on May 17th 2022 (about 2 years)

Aging – a process that began the moment we were born – is generally thought of as inevitable. But could aging become reversible in the future? Technologies l...

Posted on April 30th 2022 (about 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on April 28th 2022 (about 2 years)

Dr. Dominic D'Agostino discusses how ketones affect exercise performance, reduce inflammation, and improve neurological health.

Posted on April 26th 2022 (about 2 years)

The idea of aging "gracefully" – looking, feeling, and thinking well as the years pass – is not only appealing, but (science suggests) also achievable. Exerc...

Posted on April 19th 2022 (about 2 years)

Multiple sclerosis (MS) is an autoimmune neurodegenerative disorder that destroys myelin, the insulating layer that surrounds neurons. The causes of MS are c...

Posted on April 13th 2022 (about 2 years)

MedCram co-founder Kyle Allred discusses sauna's exercise mimetic, anti-inflammatory, mood-elevating, and detoxifying properties in this episode.

Posted on April 11th 2022 (about 2 years)

Dr. Morgan Levine discusses epigenetics and the application of epigenetic aging clocks in quantifying human aging.

Posted on April 2nd 2022 (about 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on April 1st 2022 (about 2 years)

In response to cold-water immersion, the body increases circulation of norepinephrine. This physiological response sets off a cascade of adaptive effects that affect metabolism, the brain, and genetic expression.

Posted on March 30th 2022 (about 2 years)

Autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, and multiple sclerosis occur when the immune system mistakes the body's own proteins for t...

Posted on March 22nd 2022 (about 2 years)

A healthy intestinal barrier limits the transport of pathogens and endotoxins from the gut to the bloodstream; however, increased gut permeability (known as ...

Posted on March 9th 2022 (over 2 years)

Dr. Peter Diamandis and Tony Robbins discuss the application of precision medicine and health technologies in slowing human aging.

Posted on March 5th 2022 (over 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on March 2nd 2022 (over 2 years)

The cardioprotective effects of omega-3s are pretty well established. But the research on omega-3s has also revealed that they're involved in nearly every as...

Posted on February 8th 2022 (over 2 years)

Dr. Eran Elinav discusses the complex interactions between humans and their resident gut microbiomes.

Posted on February 5th 2022 (over 2 years)

Early studies of omega-3 fatty acid intake demonstrated dramatic biological effects. Since then, the body of research enumerating the profound anti-inflammat...

Posted on February 5th 2022 (over 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on January 25th 2022 (over 2 years)

Small changes can make big differences in how long and how well we live. Diet stands out as low-hanging fruit for influencing our lifespan. Optimizing macron...

Posted on January 18th 2022 (over 2 years)

The arrival of a new year is a great opportunity to make health-focused resolutions – promises to ourselves that we're going to live better, healthier, and (...

Posted on January 8th 2022 (over 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on December 30th 2021 (over 2 years)

Many people suffer from insomnia, which is often driven by change, especially change that affects relationships, employment, or family dynamics. Cognitive be...

Posted on December 30th 2021 (over 2 years)

Circadian rhythms play key roles in metabolic health and ultimately influence body weight, performance, and susceptibility to diseases like diabetes and canc...

Posted on December 28th 2021 (over 2 years)

This episode discusses qualities of the psychedelic experience that most lend psilocybin to be potentially therapeutically beneficial for depression.

Posted on December 15th 2021 (over 2 years)

Overeating – whether it's an occasional practice or a chronic problem – can promote weight gain and a host of other health problems such as type 2 diabetes a...

Posted on December 10th 2021 (over 2 years)

While infection with the SARS-CoV-2 virus shares symptoms with the common cold and influenza such as sore throat, cough, and runny nose, there are critical d...

Posted on December 7th 2021 (over 2 years)

Dr. Bill Harris discusses the roles that omega-3 fatty acids play in cardiovascular and neurocognitive health.

Posted on December 4th 2021 (over 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 29th 2021 (over 2 years)

This episode has the answers to hot topic questions about the COVID-19 vaccines, such as: Is the spike protein made from the vaccines dangerous? Will the vac...

Posted on November 6th 2021 (over 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 5th 2021 (over 2 years)

Protein is essential for maintaining muscle mass as we age. Modulating protein intake via dietary intake or fasting can have variable effects on aging and mu...

Posted on November 2nd 2021 (over 2 years)

Dr. Ashley Mason discusses the practice of cognitive behavioral therapy and sauna use in treating depression.

Posted on October 26th 2021 (over 2 years)

The classic ketogenic diet is high in fat and low in protein and carbohydrates. The ease of following a ketogenic diet varies from person to person, dependin...

Posted on October 22nd 2021 (over 2 years)

Regulating the amount of light in our environment is crucial for a good night's sleep and a good mood the next day. Habits such as using blue light-emitting ...

Posted on October 21st 2021 (over 2 years)

When a person consumes a ketogenic diet, profound metabolic changes occur as the body shifts from burning glucose to using fatty acids and ketones. These cha...

Posted on October 21st 2021 (over 2 years)

Eating a typical Western diet – high in processed foods and sugar-sweetened beverages – raises blood glucose and insulin levels, promotes inflammation, and c...

Posted on October 21st 2021 (over 2 years)

Zinc is an essential nutrient that participates in many biological processes and plays critical roles in immune function, protein synthesis, wound healing, D...

Posted on October 21st 2021 (over 2 years)

In recent decades, lifestyle practices have emerged as viable strategies for treating symptoms of depression. Online resources that combine healthful practic...

Posted on October 21st 2021 (over 2 years)

Inflammation is an important aspect of immunity. Robust evidence indicates that increased inflammation is linked with depression. Some scientists think that ...

Posted on October 21st 2021 (over 2 years)

The physiological responses to sauna use are incredibly similar to those experienced during moderate- to vigorous-intensity exercise. As a result, sauna use ...

Posted on October 21st 2021 (over 2 years)

Diet plays an essential role in immune function. Consequently, deficiencies or insufficiencies in vitamins or minerals can impair immune function. The gut mi...

Posted on October 21st 2021 (over 2 years)

Statins can reduce the risk of heart disease by 30 to 40 percent due to their ability to increase LDL receptor activity and reduce blood cholesterol levels. ...

Posted on October 21st 2021 (over 2 years)

Vitamin D is a hormone produced in the body. People who have poor vitamin D status are more likely to test positive for COVID-19. In the setting of COVID-19,...

Posted on October 21st 2021 (over 2 years)

Airplanes are closed, cramped spaces that seem ideal for COVID-19 transmission. Even so, surprisingly few COVID-19 infections have been reported from air tra...

Posted on October 21st 2021 (over 2 years)

Cholesterol is vital to human health, but an oversimplified view of cholesterol — that high-density lipoprotein (HDL) cholesterol is good, and low-density li...

Posted on October 21st 2021 (over 2 years)

Having a healthy, robust immune system is crucial for our survival. Critical players in the body's antiviral immune response are interferons. Certain lifesty...

Posted on October 20th 2021 (over 2 years)

Sleep affects aspects of our mental and cognitive health. Not getting enough sleep triggers the onset of a "loneliness phenotype," driving people who are sle...

Posted on October 20th 2021 (over 2 years)

Poor sleep reduces the body's insulin sensitivity and changes a person's appetite, increasing the preference for high carbohydrate foods like pizza, pasta, a...

Posted on October 20th 2021 (over 2 years)

Traditional vaccines take many years to develop. A recent innovation in vaccine technology involves exploitation of messenger RNA, or mRNA, to facilitate rap...

Posted on October 20th 2021 (over 2 years)

Coffee consumption is associated with protection from several chronic diseases. Coffee's beneficial effects may stem from its ability to induce autophagy; ho...

Posted on October 20th 2021 (over 2 years)

Keeping our brains sharp throughout the lifespan is essential for optimal performance. Lifestyle behaviors such as exercise, dietary modification, and sauna ...

Posted on October 20th 2021 (over 2 years)

Recent discoveries in the field of epigenetics suggest we might be able to slow aging, based on the realization that not everyone ages at the same rate. Evid...

Posted on October 20th 2021 (over 2 years)

This is a special mashup episode, featuring a collection of clips on a range of topics related to supplements — including Rhonda’s evolving supplement routin...

Posted on October 20th 2021 (over 2 years)

Parkinson's disease is a progressive neurodegenerative disorder with no cure. It typically manifests later in life and is caused by the destruction of neuron...

Posted on October 20th 2021 (over 2 years)

Although many beneficial effects of time- or calorie-restricted eating in humans have been identified, many questions still remain regarding fitness and perf...

Posted on October 20th 2021 (over 2 years)

Circadian rhythms modulate a wide array of the body's physiological processes, ultimately influencing body weight, performance, and susceptibility to disease...

Posted on October 20th 2021 (over 2 years)

Autophagy, a type of cellular recycling program, influences many aspects of health and disease, including cancer, neurodegenerative disease, and aging. Nutri...

Posted on October 20th 2021 (over 2 years)

Chronic stress impacts our mental and physical health. Stress increases levels of hormones like adrenaline and cortisol, which in turn, can increase a person...

Posted on October 20th 2021 (over 2 years)

Sulforaphane exerts beneficial – and somewhat unconventional – effects in humans to promote health. For example, sulforaphane promotes the urinary excretion ...

Posted on October 19th 2021 (over 2 years)

“If you can not measure it, you can not improve it.” - William Thompson Getting regular checkups and undergoing blood tests are fundamental to maintaining...

Posted on October 6th 2021 (over 2 years)

Dr. Mark Mattson discusses how stress is essential to human survival and how exercise and intermittent fasting induce stress to promote health.

Posted on October 2nd 2021 (over 2 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on September 27th 2021 (over 2 years)

Dr. Rhonda Patrick and MedCram founders Dr. Roger Seheult and physician assistant Kyle Allred discuss COVID-19 vaccines.

Posted on September 4th 2021 (almost 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on August 18th 2021 (almost 3 years)

Compared to people with the lowest blood concentrations of EPA and DHA (combined), those with the highest blood concentrations were as much as 17 percent less likely to die from all causes of premature death.

Posted on August 14th 2021 (almost 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 10th 2021 (almost 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 5th 2021 (almost 3 years)

Eating too much or too little generally has obvious effects on our health. But a growing body of evidence suggests that when we eat matters, too. Late-night ...

Posted on July 5th 2021 (almost 3 years)

Mounting evidence demonstrates that various forms of fasting may be beneficial as a complementary treatment against cancer. Fasting makes cancer cells more v...

Posted on June 15th 2021 (about 3 years)

Dr. Satchidananda Panda discusses circadian rhythms, the day-night cycles that drive the multifaceted activities of the human body.

Posted on June 5th 2021 (about 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on May 26th 2021 (about 3 years)

Sulforaphane, an isothiocyanate compound derived from broccoli sprouts and certain cruciferous vegetables, exerts a wide range of beneficial effects in human...

Posted on May 26th 2021 (about 3 years)

The conversion of glucoraphanin to sulforaphane in broccoli sprouts requires myrosinase, an enzyme co-located within the leaves, stems, and other components ...

Posted on May 26th 2021 (about 3 years)

Sulforaphane switches on mechanisms that protect against cancer and other environmental insults. Sulforaphane is produced when the plants' cells are damaged ...

Posted on May 26th 2021 (about 3 years)

Sulforaphane, an isothiocyanate compound, is the most potent naturally occurring inducer of the body's key detoxification enzymes. While sulforaphane is deri...

Posted on May 26th 2021 (about 3 years)

Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly eve...

Posted on May 26th 2021 (about 3 years)

Time-restricted eating, which involves taking in food within a small window of time during the day and fasting for the remainder, can improve certain biomark...

Posted on May 26th 2021 (about 3 years)

Various ancient practices, including meditation, hot yoga, and sauna, may aid in the treatment of depression. Whether the medical community will embrace thes...

Posted on May 26th 2021 (about 3 years)

Roughly one-quarter of people living in the US carry a genetic variant of the apolipoprotein E gene, called APOE4, the most important genetic risk factor for...

Posted on May 26th 2021 (about 3 years)

People who have depression often have elevated biomarkers of inflammation. These markers can chronically activate the body's inflammatory response system, pr...

Posted on May 26th 2021 (about 3 years)

This episode of the aliquot features a collection of clips covering a range of topics related to fasting - both intermittent and prolonged. Specific topics ...

Posted on May 26th 2021 (about 3 years)

This collection of clips covers some of the many health benefits associated with the use of traditional Finnish saunas and other forms of whole-body hyperthe...

Posted on May 26th 2021 (about 3 years)

In this first episode of the Aliquot podcast, Rhonda discusses topics such as her pre-pregnancy diet, exercise, and sleep; which supplements she included and...

Posted on May 24th 2021 (about 3 years)

Dr. Michael Snyder discusses personalized medicine and the use of technologies that monitor metabolism and other health markers.

Posted on May 1st 2021 (about 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on April 14th 2021 (about 3 years)

In this short video, Dr. Rhonda Patrick describes one of the mechanisms that drives the beneficial effects of sleep on the brain.

Posted on April 10th 2021 (about 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on March 6th 2021 (over 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on February 6th 2021 (over 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on February 3rd 2021 (over 3 years)

Dr. Roger Seheult discusses the roles of vaccines, vitamin D, and heat therapy in the prevention of COVID-19.

Posted on January 9th 2021 (over 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on December 18th 2020 (over 3 years)

Dr. Steve Horvath discusses epigenetic aging clocks and their use in predicting biological aging and healthspan.

Posted on December 11th 2020 (over 3 years)

Dr. Steve Horvath found a way to measure biological aging – a type of "clock" – based on the methylation pattern of an organism's genome. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath.

Posted on December 5th 2020 (over 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 16th 2020 (over 3 years)

Broccoli sprouts contain more glucoraphanin, the precursor to sulforaphane, than mature broccoli. Glucoraphanin activates the Nrf2 pathway to protect cells from oxidative stress and damage. In this episode, we describe the basics of sprouting broccoli seeds.

Posted on November 16th 2020 (over 3 years)

A special two-hour Q&A with Dr. Jed Fahey, an expert on sulforaphane, chemoprotection, and phytochemicals.

Posted on October 13th 2020 (over 3 years)

Dr. Giselle Petzinger discusses new findings in Parkinson's disease research, emphasizing exercise's role in delaying disease progression.

Posted on October 3rd 2020 (over 3 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on September 5th 2020 (almost 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on August 25th 2020 (almost 4 years)

Comprehensive overview: Breast milk's nutritional and non-nutritional components, and health benefits for mother and infant through breastfeeding

Posted on August 1st 2020 (almost 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 11th 2020 (almost 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on June 10th 2020 (about 4 years)

COVID-19 Q&A Part 2: Rhonda Patrick, Ph.D. answers subscriber questions in a multi-part series.

Posted on June 6th 2020 (about 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on May 17th 2020 (about 4 years)

Dr. Rhonda Patrick makes her ninth appearance on the Joe Rogan Experience.

Posted on May 12th 2020 (about 4 years)

Dr. Patrick covers vitamin C's diverse aspects: bioavailability, immune function, viral protection, lung health, cancer impact, exercise effects, and more!

Posted on May 2nd 2020 (about 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on April 14th 2020 (about 4 years)

COVID-19 Q&A Series Part 1: Rhonda Patrick, Ph.D. addresses subscriber questions in this multi-part series.

Posted on April 4th 2020 (about 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on March 7th 2020 (over 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on February 8th 2020 (over 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on January 29th 2020 (over 4 years)

Rhonda explains NAD+: importance for aging, decline with age, boosters (nicotinamide riboside, nicotinamide mononucleotide), and data in animals and humans.

Posted on January 8th 2020 (over 4 years)

Dr. Rhonda Patrick on Kevin Rose Show: metformin, magnesium L-threonate, fish oil, brain health, sulforaphane, goitrogenic activity, sauna, and more.

Posted on January 4th 2020 (over 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on December 30th 2019 (over 4 years)

Resveratrol's science, effects in animals and humans, mechanisms, supplementation, and safety.

Posted on December 6th 2019 (over 4 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 6th 2019 (over 4 years)

Dr. David Sinclair discusses the mechanisms that drive human aging and the importance of identifying ways to slow or reverse aging's effects.

Posted on September 10th 2019 (almost 5 years)

Sauna use boosts lifespan and overall health supported by compelling data from observational, interventional, and mechanistic studies.

Posted on August 5th 2019 (almost 5 years)

Dr. Patrick discusses some of the compelling evidence that suggests exercise is a tool for preventing or managing the symptoms of depression.

Posted on June 10th 2019 (about 5 years)

Dr. Elissa Epel discusses the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health.

Posted on May 21st 2019 (about 5 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on April 2nd 2019 (about 5 years)

The production of melatonin begins to increase 2-3 hours before our normative bedtime, which may be a signal to the pancreas to begin suppressing the production of insulin.

Posted on March 13th 2019 (over 5 years)

Several studies have established causation showing that sleep duration is a major determinant of insulin sensitivity.

Posted on February 28th 2019 (over 5 years)

Dr. Matthew Walker discusses the role of sleep in immunity, creativity, and aging.

Posted on January 17th 2019 (over 5 years)

This episode features a Q&A session on fasting-related topics with Dr. Rhonda Patrick and Mike Maser of Zero Fasting Tracker.

Posted on October 2nd 2018 (over 5 years)

Dr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience.

Posted on October 1st 2018 (over 5 years)

Dr. Dale Bredesen discusses treatments that may reverse symptoms of mild cognitive decline and Alzheimer’s disease.

Posted on August 31st 2018 (almost 6 years)

This short recipe video shows a fun, tasty way to eat salmon roe. Salmon roe is rich in the omega-3 fatty acid, docosahexaenoic acid, in its phospholipid form.

Posted on August 26th 2018 (almost 6 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 9th 2018 (almost 6 years)

Dr. Valter Longo discusses fasting as a means to treat or prevent age-related diseases such as cancer, Alzheimer’s disease, and others.

Posted on March 19th 2018 (over 6 years)

Dr. Charles Raison discusses the role inflammation plays in the development of depression in response to illness and stress.

Posted on March 11th 2018 (over 6 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on December 21st 2017 (over 6 years)

Dr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience.

Posted on December 13th 2017 (over 6 years)

Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

Posted on December 10th 2017 (over 6 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on November 27th 2017 (over 6 years)

Several associative studies that have found a link between saturated fat and heart disease... should we be concerned?

Posted on November 16th 2017 (over 6 years)

This is a video on how to plausibly increase the sulforaphane created from the glucoraphanin in your broccoli sprouts by up to 3.5-fold.

Posted on November 8th 2017 (over 6 years)

Our genes influence the way we absorb and metabolize micronutrients. Nutrigenomics looks at the influence genetic variation has over micronutrient absorption/metabolism and the biological consequences of this dynamic relationship.

Posted on November 8th 2017 (over 6 years)

In this video Dr. Rhonda Patrick shares her recipe for low-carb lemon tart and demonstrates how to make it.

Posted on November 8th 2017 (over 6 years)

Dan Pardi: Ph.D. candidate studying sleep neurobiology at Stanford and University of Leiden, co-founder of Dan’s Plan online wellness company.

Posted on November 8th 2017 (over 6 years)

Dr. Rhonda Patrick talks about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.

Posted on October 30th 2017 (over 6 years)

Dr. Satchin Panda discusses the practical aspects of implementing fasting, time-restricted eating, shift work strategies, and more.

Posted on October 7th 2017 (over 6 years)

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Posted on July 31st 2017 (almost 7 years)

Dr. Guido Kroemer discusses immunology, cancer biology, calorie-restriction mimetics, aging, and autophagy.

Posted on June 15th 2017 (about 7 years)

Dr. Jari Laukkanen discusses the role of heat stress in the prevention of cardiovascular & Alzheimer’s disease.

Posted on April 28th 2017 (about 7 years)

Dr. Judith Campisi discusses the role of cellular senescence in the aging process and the development of cancer.

Posted on April 7th 2017 (about 7 years)

Dr. Gordon Lithgow discusses the roles of protein aggregation, iron overload, and others in the aging process.

Posted on March 18th 2017 (over 7 years)

Science on refined sugar: mortality, aging, brain function, memory, neuroinflammation, cancer, sex hormones, addiction & more.

Posted on March 18th 2017 (over 7 years)

Systemic inflammation is an important mechanism that research shows may have a very interesting relationship with depression.

Posted on January 19th 2017 (over 7 years)

Dr. Jed W. Fahey discusses the health benefits of isothiocyanates, including sulforaphane and moringa.

Posted on January 19th 2017 (over 7 years)

Dr. Roland Griffiths discusses the effects of the psychedelic compound psilocybin on the human brain.

Posted on January 19th 2017 (over 7 years)

Dr. Rhonda Patrick makes her fifth appearance on the Joe Rogan Experience.

Posted on December 14th 2016 (over 7 years)

This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.

Posted on October 4th 2016 (over 7 years)

Dr. Valter Longo discusses the role of fasting and the fasting-mimicking diet in longevity, cancer & multiple sclerosis.

Posted on July 8th 2016 (almost 8 years)

Dr. Ruth Patterson discusses the role of fasting in the prevention and survivorship of breast cancer.

Posted on July 1st 2016 (almost 8 years)

Dr. Satchin Panda discusses the roles that fasting, time-restricted eating, and circadian rhythms play in human health.

Posted on May 31st 2016 (about 8 years)

A modest change on the "micronutrient smoothie" that also talks about the beneficial compounds that don't qualify as micronutrients.

Posted on May 4th 2016 (about 8 years)

Ray Cronise discusses the roles that cold stress, intermittent fasting, and weight loss play in human healthspan.

Posted on April 10th 2016 (about 8 years)

Dr. Dominic D'Agostino discusses the health benefits associated with a modified Atkins diet, ketosis, and supplemental ketones.

Posted on March 14th 2016 (over 8 years)

Dr. Peter Attia discusses dietary strategies to promote longevity and optimal performance.

Posted on February 12th 2016 (over 8 years)

Dr. Rhonda Patrick explains cold shock as hormesis, a beneficial stressor that triggers adaptive processes, promoting resilience.

Posted on January 24th 2016 (over 8 years)

Rich Roll shares his thoughts on self-transformation, the environmental impact of food, and the benefits of eating a plant-based diet.

Posted on January 3rd 2016 (over 8 years)

Dr. Darya Rose & husband Kevin Rose discuss the benefits of meditation, seasonal eating, and more.

Posted on January 3rd 2016 (over 8 years)

Dr. Pierre Capel discusses cold stress, Wim Hof, genetic modification, and cancer immunotherapy.

Posted on January 3rd 2016 (over 8 years)

Wim Hof discusses his unique breathing technique and how it helps him withstand cold stress.

Posted on January 3rd 2016 (over 8 years)

Dr. Patrick's keynote lecture at MBOG Congres 2015 in the Netherlands covers micronutrient inadequacy and Dr. Bruce Ames' triage theory.

Posted on January 3rd 2016 (over 8 years)

This episode is a presentation Dr. Rhonda Patrick delivered at the Biohacker Summit in Helsinki, Finland in 2016.

Posted on January 3rd 2016 (over 8 years)

Drs. Erica and Justin Sonnenburg both research the interaction between diet and the trillions of bacteria in the gut.

Posted on January 3rd 2016 (over 8 years)

Dr. Ronald Krauss discusses the role that LDL cholesterol plays in heart disease, dyslipidemia, and atherosclerosis.

Posted on September 25th 2015 (over 8 years)

Rhonda explains chronic stress's impact on brain, gut, immune system, and aging. Meditation buffers and improves cognitive and biological aging.

Posted on August 13th 2015 (almost 9 years)

Dr. Aubrey de Grey discusses technologies that can repair the various types of damage that occur during the aging process.

Posted on July 21st 2015 (almost 9 years)

Tim Ferriss discusses ketosis, the gut microbiome, and monitoring biomarkers to promote performance.

Posted on July 4th 2015 (almost 9 years)

Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.

Posted on April 28th 2015 (about 9 years)

In this video, Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with increased decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per week decreased all-cause mortality by 40%.

Posted on March 23rd 2015 (about 9 years)

This video breaks down, point-by-point what gene polymorphisms you might look at, and how they relate to very specific micronutrients.

Posted on February 12th 2015 (over 9 years)

Is cancer just bad luck? To some degree, yes... but there's also a very, very large environmental and lifestyle component.

Posted on February 12th 2015 (over 9 years)

Dr. Bruce Ames discusses his triage theory.

Posted on December 17th 2014 (over 9 years)

Dr. Frans Kuypers discusses his technique to retrieve pluripotent stem cells from placental tissue.

Posted on December 3rd 2014 (over 9 years)

Dr. George Brooks discusses the metabolic pathway known as the “lactate shuttle" and its role in the recovery from traumatic brain injury.

Posted on October 27th 2014 (over 9 years)

Dr. Rhonda Patrick makes her third appearance on the Joe Rogan Experience.

Posted on September 29th 2014 (over 9 years)

There may be something special about sources of omega-3 that are richer in the phosphatidylcholine form of DHA.

Posted on August 5th 2014 (almost 10 years)

Dr. Rhonda Patrick explains what antioxidants are, why they are important, and how they prevent DNA damage, a well-known cancer initiator.

Posted on July 22nd 2014 (almost 10 years)

Dr. Terry Wahls discusses the nutrition protocol she used to reverse her secondary-progressive multiple sclerosis.

Posted on June 21st 2014 (almost 10 years)

Dr. Rhonda Patrick is on The Tim Ferriss Show in episode #12 entitled "Rhonda Patrick on Life Extension, Performance, and More".

Posted on May 16th 2014 (about 10 years)

Decreased consumption of chlorophyll containing vegetables, decreased absorption, and increased excretion is largely the primary reasons why apprximately 45% of US population is deficient in magnesium.

Posted on May 16th 2014 (about 10 years)

Dr. Patrick describes how magnesium, an essential mineral that ~56% of the US population is deficient in, can help you maximize your mitochondria to increase oxidative capacity and, potentially, enhance exercise performance.

Posted on May 16th 2014 (about 10 years)

Dr. Rhonda Patrick makes her second appearance on the Joe Rogan Experience.

Posted on April 10th 2014 (about 10 years)

Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass.

Posted on February 20th 2014 (over 10 years)

Dr. Rhonda Patrick makes her first appearance on the Joe Rogan Experience.

Posted on February 1st 2014 (over 10 years)

In this podcast, we discuss and critically analyze a recent headline-grabbing editorial that was published in the Annals of Internal Medicine that reviewed three studies on the topic of multivitamins and chronic disease prevention. We analyze the important shortcomings of the studies and talk about the mechanism.