Small changes can make big differences in how long and how well we live. Diet stands out as low-hanging fruit for influencing our lifespan. Optimizing macronutrient intake, practicing time-restricted eating, and consuming healthful bioactive compounds are critical aspects of a healthy diet. In part II of this two-part Aliquot, Drs. Peter Attia, Guido Kroemer, Jed Fahey, and David Sinclair discuss nutritional considerations for living healthier, longer lives.