Aliquot #102: The Future of Aging Therapeutics, Part 1
Aliquot #102: The Future of Aging Therapeutics, Part 1
Researchers in the field of aging science have identified nine hallmarks of aging – observable biological patterns of dysfunction that occur as an organism ages. Scientists are exploring a wide range of cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.
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Researchers in the field of aging science have identified nine hallmarks of aging – observable biological patterns of dysfunction that occur as an organism ages. Scientists are exploring a wide range of cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.
In this Aliquot, part I of this two-part series on the future of aging research, I present an overview of the hallmarks of aging and describe some of the recent advances in aging research.
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The nine (cellular and molecular) hallmarks of aging
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The impact of phenotypic aging
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What genomic instability means for aging
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Why mitochondria matter and how to repair them
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What do epigenetic clocks tell us about aging?
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What makes our biological clocks 'tick' faster or slower?
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At what point does the aging process start?
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The first human induced stem cell therapy
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Transforming skin cells into neurons
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Rejuvenation vs. cellular identity — striking a balance
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The dose makes the difference
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The brief touch of youth through Yamanaka factors
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