Popular Topics

Vitamin C

Vitamin C is an essential nutrient, widely recognized for its antioxidant properties and its roles in many critical processes and pathways.

Zinc

Zinc is an essential nutrient that influences growth and development and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.

Omega-3 fatty acids

Omega-3 fatty acids play critical roles in human health and may be beneficial in ameliorating symptoms associated with chronic health conditions and in combating aging-related diseases.

Brain-derived neurotrophic factor (BDNF)

BDNF is a growth factor known for its influence on neuronal health and for its role in mediating the beneficial cognitive effects associated with exercise.

Sauna

Sauna use exposes the body to extreme heat and, in turn, induces protective responses that improve health and may increase healthspan.

Cold exposure

Cold exposure may act as a hormetic stressor to reduce inflammation, activate antioxidant enzymes, and boost the immune system to protect against age-related diseases.

Search Topics

A
  • Aerobic exercise
    Aerobic exercise, physical activity that increases breathing and heart rate, promotes cardiovascular, brain, and whole-body health.
  • Autophagy
    Autophagy, or “self-eating,” is a response to stress in which a cell destroys damaged or dysfunctional components in order to adapt to external conditions.
B
  • Berberine
    Berberine is a plant-based compound with pharmacological actions that share many features with metformin.
  • Beta-hydroxybutyrate
    Beta-hydroxybutyrate (BHB) is a ketone body and source of cellular energy produced via the breakdown of fats during times of carbohydrate scarcity and fasting.
  • Blood-brain barrier
    The blood-brain barrier comprises the sets of membranes that separate the central nervous system (CNS) and the peripheral circulatory system. This barrier allows passage of nutrients and cell signals from the bloodstream to the CNS while excluding harmful substances.
  • Brain-derived neurotrophic factor (BDNF)
    BDNF is a growth factor known for its influence on neuronal health and for its role in mediating the beneficial cognitive effects associated with exercise.
  • Breast milk and breastfeeding
    Breast milk is a complex, dynamic fluid that contains nutritional and non-nutritional components that positively influence an infant's development. Breastfeeding benefits both infants and mothers.
  • Butyrate
    A short-chain fatty acid produced by microbes in the gut. Microbial production of butyrate occurs in the colon during the fermentation of dietary fibers.
C
  • Caloric Restriction
    Caloric restriction is the practice of long-term reduced energy intake. It delays the onset of age-related chronic diseases in animals.
  • Carotenoids
    Carotenoids, such as lutein and zeaxanthin, are bioactive plant compounds with eye and brain benefits.
  • Cold exposure
    Cold exposure may act as a hormetic stressor to reduce inflammation, activate antioxidant enzymes, and boost the immune system to protect against age-related diseases.
  • Creatine
    Creatine is a naturally occurring compound best known for its widespread use as a dietary supplement to enhance physical performance.
D
  • Depression
    Depression – a neuropsychiatric disorder affecting 322 million people worldwide – is characterized by negative mood and metabolic, hormonal, and immune disturbances.
E
  • Epigenetic aging clocks
    Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile.
F
  • Fasting
    Fasting – the voluntary abstinence from food and drink – is an ancient practice now widely appreciated for its beneficial effects on healthspan.
  • FOXO
    FOXO proteins are transcriptional regulators that play an important role in healthy aging. Some FOXO genes may increase lifespan.
G
H
  • Hallmarks of aging
    The hallmarks of aging are observable biological patterns of dysfunction that accrue in a biological organism over time.
  • Hydrolyzed collagen
    Hydrolyzed collagen is a mixture of smaller peptides derived from the protein collagen that may improve skin aging, decrease arthritis induced pain, increase bone mineral density, and decrease hypertension.
I
  • Intestinal permeability
    Intestinal permeability determines how well the GI tract absorbs nutrients and excludes dangerous particles from the environment such as pathogens and toxins.
J...K
L
  • Lactobacillus reuteri
    Lactobacillus reuteri is a probiotic bacterium that regulates the immune system, reduces cholesterol, and prevents diarrheal disease.
M
  • Metformin
    Metformin, a drug commonly used to treat type 2 diabetes, may modulate certain aging processes.
N
  • NAD+
    NAD+ is a cofactor that plays an essential role in metabolism, DNA repair, and immunity. Its depletion accelerates aging.
  • Neu5Gc
    Neu5Gc is a sialic acid produced in many mammals but not in humans. It is found in red meat and other animal products and has been found to accumulate in some human tissues.
  • Nicotinamide mononucleotide
    Nicotinamide mononucleotide is a precursor of NAD+, a coenzyme necessary for cellular energy production and DNA repair. It is available as a supplement.
  • Nicotinamide riboside
    Nicotinamide riboside is a precursor of NAD+, a coenzyme necessary for energy production and cellular repair. It is available from food and supplements.
O
  • Omega-3 fatty acids
    Omega-3 fatty acids play critical roles in human health and may be beneficial in ameliorating symptoms associated with chronic health conditions and in combating aging-related diseases.
P
  • Polyphenols
    Polyphenols are bioactive plant compounds with a wide range of health benefits.
Q
  • Quercetin
    Quercetin is a plant-based bioactive compound that exerts antioxidant, anti-inflammatory, and anti-aging properties across multiple organ systems.
R
  • Resveratrol
    Resveratrol is a polyphenolic compound produced in plants that demonstrates anti-inflammatory and anti-aging properties in humans.
S
  • Salmon roe
    Salmon roe, the internal egg mass found in female salmon, is rich in protein, vitamins, and the omega-3 fatty acids EPA and DHA.
  • Sauna
    Sauna use exposes the body to extreme heat and, in turn, induces protective responses that improve health and may increase healthspan.
  • Senescence
    Senescence is a response to stress in which damaged cells terminate normal growth cycles to prevent dysfunctional cells from reproducing.
  • Sirtuins
    Sirtuins play a key role in healthspan and longevity by regulating a variety of metabolic processes implicated in aging.
  • Small vessel disease
    Small vessel disease is a generic term that describes dysfunction of blood vessels that occurs with aging and contributes to cognitive decline, cardiovascular disease, frailty, and stroke.
  • Sugar-sweetened beverages (SSBs)
    Sugar-sweetened beverages such as soda, juice, and sports drinks provide large doses of rapidly absorbable sugar, posing a unique risk to health.
  • Sulforaphane
    Sulforaphane is a bioactive compound that exerts potent antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases.
T
  • Thymic involution
    Thymic involution is the process by which the thymus shrinks with age, reducing T cell-mediated immunity and increasing disease risk in older adults.
  • Time-restricted eating
    Time-restricted eating is a form of daily fasting wherein a person eats only during a limited time window, typically 8- to 12-hours.
  • Toll-like receptors
    Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells that play an important role in intestinal permeability and inflammaging.
U
V
  • Vitamin C
    Vitamin C is an essential nutrient, widely recognized for its antioxidant properties and its roles in many critical processes and pathways.
  • Vitamin D
    Vitamin D is a hormone that plays critical roles in many physiological processes, such as blood pressure regulation, immune function, and cell growth.
W
  • Whole-body hyperthermia
    Hyperthermia stresses the body, activating its repair mechanisms. Whole-body hyperthermia is a therapeutic strategy used to treat various medical conditions.
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Z
  • Zinc
    Zinc is an essential nutrient that influences growth and development and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.