By becoming a member of FoundMyFitness premium, you'll receive the Science Digest every-other-week covering the latest in my exploration of recent science and the emerging story of better living — through deeper understandings of biology.
- Ketogenic diet, by replacing glucose with ketones as an energy source, lessens alcohol cravings among people with alcohol use disorders.
- Omega-3 fatty acids reduce the risk of cardiovascular disease-related death by up to 23 percent, especially in people with high triglyceride levels.
- Women see a 24 percent drop in premature death risk with just 140 minutes of weekly activity – half the time men need for similar benefits.
- Aging undermines the brain's capacity for maintaining working memory, with subtle declines in neuron activity and connectivity in the prefrontal cortex.
Millions of women worldwide experience pelvic pain, heavy periods, and infertility due to endometriosis, a poorly understood gynecological disease. Despite the condition’s prevalence, current treatments for endometriosis provide limited relief and often require invasive diagnostic procedures. A recent study found that bacteria in the gut may be instrumental in diagnosing and treating endometriosis.
Researchers analyzed stool samples from women with and without endometriosis to investigate links between gut bacteria and the disease. Then, they tested the potential therapeutic effects of key metabolites produced by gut bacteria using animal models.
They identified a distinct pattern of bacteria-derived metabolites in the stool of women with endometriosis that closely resembled those found in inflammatory bowel disease. One metabolite, 4-hydroxyindole, was considerably lower in women with the condition. Notably, this compound prevented the development of endometriotic lesions and reduced pain in the animal models.
These findings suggest that gut bacteria play a critical role in the progression of endometriosis and that 4-hydroxyindole could be a promising non-invasive diagnostic marker and therapy for the disease. Learn how gut bacteria influence many other aspects of human health in this episode featuring Dr. Eran Elinav.
Iron is an essential nutrient that participates in oxygen transport, energy production, and other critical processes. However, iron can accumulate in the brain, impairing memory and thinking abilities, especially in conditions like Alzheimer’s. A recent study found that older adults with higher brain iron levels perform poorly on cognitive tests.
Researchers used specialized MRI techniques to measure iron levels and atrophy in the brains of 770 older adults. Of these participants, 219 underwent cognitive testing roughly every year for about three years. The researchers focused on crucial brain regions associated with normal aging and Alzheimer’s disease to explore the relationship between iron buildup, brain atrophy, and cognitive performance.
They found that higher iron levels were linked to worse cognitive performance, particularly in memory and attention. Participants with the highest iron levels in aging-related brain regions were more likely to experience cognitive decline over time, performing up to 10% worse on cognitive tests than those with lower iron levels. Additionally, increased iron levels corresponded with more severe brain atrophy in these regions.
These findings suggest that brain iron accumulation impairs cognitive function and may be an early warning sign for the condition. Other lifestyle factors contribute to cognitive losses and brain atrophy, too, including alcohol consumption. Learn more in this episode featuring Dr. Rhonda Patrick.
Asthma affects millions of children, and finding ways to prevent it before birth could be a game-changer. Some evidence suggests that physical activity during pregnancy promotes fetal lung development, potentially reducing children’s asthma risk. A recent study found that the children of mothers who engaged in regular physical activity during pregnancy were nearly half as likely to develop asthma.
Researchers analyzed data from 963 mother-child pairs participating in the Kuopio Birth Cohort study. They gathered information on maternal physical activity during pregnancy, potential influencing factors, and asthma diagnoses in the children when they were between the ages of 5 and 7 years.
They found that the children of mothers who engaged in physical activity three or more times per week during pregnancy were 46% less likely to develop asthma. This relationship held steady even after adjusting for factors like the length of pregnancy, delivery method, maternal health conditions, and family environment.
These findings suggest that regular physical activity during pregnancy could effectively reduce asthma risk in children. Experts recommend that pregnant women aim for about 150 minutes of moderate-intensity exercise every week. Learn about other healthy lifestyle practices for pregnancy in Aliquot #100: Optimizing for a Healthy Pregnancy and Early Childhood.
