00:01:56 - Daily coffee drinking and Alzheimer’s risk.
00:02:28 - Epidemiological and preclinical studies support the protective effect of coffee/caffeine on Alzheimer’s disease. [1](https://www.ncbi.nlm.nih.gov/pubmed/19158424), [2](https://www.sciencedirect.com/science/article/abs/pii/S0306452206009377)
00:02:44 - Study suggests that a higher lifetime coffee intake is likely to contribute to lowering the risk of AD or related cognitive decline by reducing pathological cerebral amyloid deposition. [1](https://doi.org/10.1038/s41398-019-0604-5)
00:03:46 - In a randomized-controlled trial, consumption of dark roast coffee brew (500 ml/day) for 1 month caused a 23% reduction in DNA damage in white blood cells compared to baseline levels. [1](https://doi.org/10.1017/S0007114508944135)
00:05:39 - Coffee consumption may lower the risk of certain cancers up to 20% and type 2 diabetes and Parkinson’s disease up to 30%. [1](https://doi.org/10.1146/annurev-nutr-071816-064941)
00:07:15 - 6 cups of coffee per day increases plasma homocysteine concentrations. [1](https://doi.org/10.1093/ajcn/71.2.480)
00:10:10 - Comparing types of coffee: beans of coffee robusta have a higher polyphenol content than arabica beans but robusta also has more caffeine per bean. [1](https://doi.org/10.1016/j.foodchem.2011.05.059)
00:11:50 - Effect of food combining and food order on post-prandial glucose levels. [1](http://www.onlinejacc.org/content/51/3/249.abstract), [2](https://www.ncbi.nlm.nih.gov/pubmed/26106234), [3](https://doi.org/10.3177/jnsv.64.316)
00:18:18 - Comparisons of curcumin bioavailability.
00:19:57 - Piperine, found in black pepper, can increase the bioavailability of curcumin by 20-fold. [1](https://www.ncbi.nlm.nih.gov/pubmed/9619120)
00:20:32 - Crystalline curcumin in a micronized form can increase bioavailability by 28-fold. [1](https://www.ncbi.nlm.nih.gov/pubmed/21532153)
00:20:52 - Micellar curcumin (NovaSOL® Curcumin) was 277‐, 114‐, and 185‐fold more bioavailable than native curcumin in women, men, and all subjects, respectively. [1](https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201300724)
00:22:21 - Curcuminoid absorption was approximately 29-fold higher for the Phytosome formulation compared to the unformulated curcumin. [1](https://pubs.acs.org/doi/10.1021/np1007262), [2](https://linkinghub.elsevier.com/retrieve/pii/S2095496418300773)
00:23:00 - Does curcumin blunt the beneficial effects of exercise like high-dose vitamin C or metformin?
00:32:38 - Reducing saturated fat intake has been shown to lower ApoB in RCTs. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293238/)
00:36:30 - Lowering carbohydrate (26% E) intake and increasing saturated fat increases LDL large particles but lowers small LDL. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293238/)
00:38:22 - Inclusion of one avocado per day as part of a moderate‐fat, cholesterol‐lowering diet has LDL‐C, LDL‐P, and non‐HDL‐C lowering effects. [1](https://www.ahajournals.org/doi/full/10.1161/jaha.114.001355)
00:40:44 - APOE4 carriers had greater reductions in apolipoprotein B and plasma cholesterol than E3/E3 subjects after replacing saturated fats with low glycemic carbohydrates on a lower-fat diet. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213759/)
00:45:20 - Special considerations when considering fasting for women.
00:49:28 - Alternate day fasting may adversely affect glucose tolerance in nonobese women but not in nonobese men. [1](https://www.ncbi.nlm.nih.gov/pubmed/15833943)
00:51:10 - Sex hormones given exogenously increased ketones and betahydroxybutyrate at the 36-hour mark in both pre and postmenopausal women. [1](https://doi.org/10.1016/0026-0495(81)90151-7)
00:53:20 - Being researched: on-going randomisation, double-blind placebo-controlled study investigates the effect of menaquinone-7 (MK-7) supplementation on progression of aortic valve calcification. [1](https://bmjopen.bmj.com/content/bmjopen/8/8/e022019.full.pdf)
00:59:08 - Phylloquinone (vitamin K1) and menaquinone (vitamin K2) association with incidence of coronary heart disease (CHD), all-cause mortality, and aortic calcification. [1](https://academic.oup.com/jn/article/134/11/3100/4688389)
01:03:00 - L-carnitine (2 g/day) significantly reduced Lp(a) levels. [1](https://europepmc.org/article/med/11213533)
01:03:33 - Gene-dependent differences in response to aspirin: minor allele carriers of rs3798220 had higher Lp(a) and benefited more from an aspirin than non-carriers. [1](https://www.snpedia.com/index.php/Rs3798220)
01:05:40 - Higher serum total cholesterol is associated with a reduced PD risk in a dose-dependant manner. [1](https://www.ncbi.nlm.nih.gov/pubmed/16905642)
01:06:20 - Lower serum LDL cholesterol is associated with increased Parkinson’s disease. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906875/)
01:07:40 - FDA databases found that neurological disease was reported more often for lipophilic statins that more readily cross the blood-brain barrier, than for hydrophobic statins. [1](https://pdfs.semanticscholar.org/712a/be4f457acfed92f5cf555b11560ab050d20b.pdf)
01:11:04 - Beneficial effects of oral coenzyme Q10 administration have been found in animal models for Parkinson’s disease. [1](https://jamanetwork.com/journals/jamaneurology/fullarticle/782965)
01:14:03 - Algae as a source of marine omega-3. [1](https://www.sciencedirect.com/science/article/abs/pii/S1756464614002229), [2](https://www.sciencedirect.com/science/article/pii/S0939475317302600)
01:19:55 - Does taking direct antioxidants nullify benefits from lifestyle habits such as sauna, exercise, fasting, broccoli sprouts and others?
01:23:10 - Using a continuous glucose monitor when you don’t have diabetes.
01:29:10 - My thoughts on _moringa powder_ in my diet. [1](https://www.youtube.com/watch?v=Vt4eZ7grOk)
01:37:22 - Fish oil (omega-3 fatty acids) lowers postprandial triglyceride levels by 16% to 40% in a dose-dependent fashion. [1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563284/)
01:39:45 - Using ketone esters as an adjunct to medication for neurodegenerative diseases like Parkinson’s and Alzheimer’s. [1](https://www.foundmyfitness.com/episodes/dale-bredesen)
01:44:19 - Magnesium-L-threonate. [1](https://youtu.be/bL2rQCB46bc)
01:45:35 - Magnesium threonate 1,500-2,000 mg each day for 12 weeks improved cognitive ability relative to placebo. [1](https://www.ncbi.nlm.nih.gov/pubmed/26519439)
01:51:00 - Omega-3 DHA and prostate cancer.
01:56:55 - Collagen powder in smoothies.