In this clip, Dr. Michael Snyder describes how the human microbiome plays a key role in health, immunity, and nutrition.
In this clip, Dr. Michael Snyder describes aspects of his lifestyle routine that he tracks with wearables.
Poor air quality has been linked with effects on human health, ranging from asthma to Alzheimer's disease.
Dr. Michael Snyder describes how changes in his own glucose regulation which he noticed with a continuous glucose monitor, converging with his knowledge of his personal genetic risks, ultimately led to a surprising diagnosis of type 2 diabetes.
Genetics plays an important role in longevity, but there is also a strong lifestyle component. Dr. Snyder's research, using deep molecular measurements, indicates that when you exercise, a profound molecular change occurs — particularly when it comes to immune molecules.
Traditional medicine focuses on treating rather than preventing diseases — a model that Dr. Snyder describes as "broken."
If a participant's heart rate jumps up for a prolonged period, it might suggest a physiological response to infection.
Continuous glucose monitors, or CGMs, are wearable devices that allow users to monitor their blood glucose levels through a tiny sensor placed under the skin.
In this clip, Dr. Rhonda Patrick describes what Mendelian randomization studies are and how they are valuable instruments in the scientific toolbox.
In this clip, Dr. Roger Seheult explains how vitamin D is a misnomer and how it fulfills many critical roles in the body.
In this clip, Dr. Roger Seheult discusses how he has always had a passion for teaching and simplifying complex topics.
In this clip, Dr. Roger Seheult describes his personal experience treating COVID-19 patients in the hospital.
In this clip, Dr. Roger Seheult describes how treatment modalities differ between the two distinct phases of COVID-19 illness.
In this clip, Dr. Roger Seheult describes how mRNA vaccines stimulate the body's immune system to produce antibodies.
In this clip, Dr. Roger Seheult discusses the importance of getting enough sleep for proper immune functioning and resisting viral infections.
In this clip, Dr. Roger Seheult explains the different parts of sleep and the value of each phase.
In this clip, Dr. Roger Seheult addresses the importance of the interferon response in the body's defense against viruses.
In this clip, Dr. Roger Seheult describes how a diminished interferon response drives poor outcomes in COVID-19.
In this clip, Dr. Roger Seheult discusses the biological plausibility of incorporating heat hydrotherapy into the treatment of COVID-19.
In this clip, Dr. Roger Seheult explains that well-ventilated spaces are a factor in dampening the spread of the SARS-CoV-2 virus.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss how vitamin D levels might affect the renin-angiotensin-system and how this relates to COVID-19 outcomes.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss how to assess vitamin D requirements and its toxicity potential.
In this clip, Dr. Roger Seheult and Dr. Rhonda Patrick discuss how to assess vitamin D requirements and its toxicity potential.
In this clip, Dr. Roger Seheult describes the interesting similarity between COVID-19 risk factors and vitamin D deficiency risk factors.
In this clip, Dr. Roger Seheult explains how the current COVID-19 vaccines differ and describes his personal immunization experience.
In this clip, Dr. Steve Horvath describes research suggesting that caloric restriction, especially when it is reversing obesity or metabolic syndrome, may slow epigenetic aging.
In this clip, Dr. Steve Horvath discusses whether epigenetic clocks play causal roles in aging.
Methylation and demethylation are critical processes in development and interfering with the enzymes that carry out these two opposing processes can play critical roles in epigenetic age.
Some epigenetic clock evidence reinforces the idea that accelerated aging may be a consequence of chronic inflammation.
As techniques are developed to differentiate and transdifferentiate cells from one cell type, such as a fibroblast, into another, such as a neuron, interesting patterns of effects on epigenetic age are revealed.
A study using a mouse model of premature aging showed that short-term expression of four special factors which reverse epigenetic age ameliorated cellular and physiological hallmarks of aging and prolonged lifespan.
Scientists have observed that the epigenetic clock of transplanted cells and their descendant lineages synchronize with the donor rather than the recipient, a fascinating phenomenon that offers promise for the idea of rejuvenation in humans.
Conventional health advice, such as healthy eating, physical activity, and education level are linked with slowed epigenetic aging, albeit weakly, and obesity, sleep deprivation, and smoking are linked with accelerated epigenetic aging.
In this clip, Dr. Steve Horvath discusses how epigenetic aging differs from senescence-mediated aging.
The DNAm GrimAge epigenetic clock may be a more reliable predictor of healthspan and lifespan than traditional hallmarks of aging like telomeres.
A person's epigenetic age correlates with their risk for developing major diseases of aging like cancer, Alzheimer's disease, and Parkinson's.
The stability of methylation patterns on DNA samples means the data can be trusted more in the lab when investigating anti-aging interventions.
The GrimAge clock (named for the Grim Reaper) predicts lifespan and healthspan in units of years and tests whether potential lifestyle interventions may slow or reverse biological aging.
In this clip, Dr. Steve Horvath explains the differences between chronological age and biological age.
Sometimes a person's clinical biomarkers doesn't accurately reflect how well they are aging, but epigenetic clocks may give a more reliable insight into their aging.
Evidence indicates that the heritability of epigenetic aging is about 40 percent. This is seen in supercentenarians and their offspring, who tend to age slower than their younger counterparts.
Emerging evidence now suggests that supplemental omega-3 fatty acids or vitamin D slow epigenetic aging.
In this clip, sulforaphane expert Dr. Jed Fahey describes some of the problems associated with choosing a good source of seeds for sprouting.
In this clip, Dr. Jed Fahey enumerates the vegetables in which sulforaphane is found.
In this clip, Dr. Jed Fahey describes how long the health effects of broccoli sprouts last.
In this clip, Dr. Jed Fahey discusses how sulforaphane promotes glutathione production in the brain, even with long-term consumption.
In this clip, Dr. Jed Fahey describes how sulforaphane facilitates the detoxication of heavy metals by increasing glutathione synthesis.
In this clip, Dr. Jed Fahey describes sulforaphane's opposing effects on cancer.
In this clip, Dr. Jed Fahey discusses the effects of urinary excretion of sulforaphane byproducts.
In this clip, Dr. Jed Fahey discusses the current state of the science regarding sulforaphane and brain health.
In this clip, Dr. Jed Fahey discusses the pros and cons of sprouting and whether broccoli seeds contain erucic acid.
In this clip, Dr. Jed Fahey discusses the best protocol for maximizing glucoraphanin levels in broccoli sprouts to obtain the highest concentration of sulforaphane.
In this clip, Dr. Jed Fahey discusses strategies for disguising the flavor of broccoli sprouts.
In this clip, Dr. Jed Fahey discusses whether or not microwaving broccoli preserves the heat-sensitive myrosinase enzyme enough to convert glucoraphanin into sulforaphane.
In this clip, Dr. Jed Fahey describes how sulforaphane promotes the excretion of toxicants in air pollution.
In this clip, Dr. Jed Fahey describes the best way to store broccoli sprouts.
In this clip, Dr. Jed Fahey discusses the beneficial health effects of moringa.
In this clip, Dr. Rhonda Patrick shares anecdotal evidence that moringa reduces blood glucose levels.
In this clip, Dr. Jed Fahey names several reliable supplemental sources of sulforaphane.
In this clip, sulforaphane expert Dr. Jed Fahey describes some of the problems that complicate determining the optimal source and dose of sulforaphane.
In this clip, Dr. Jed Fahey disputes claims that sulforaphane causes goiters.
In this clip, Dr. Jed Fahey rebuts popular claims that an all-meat diet is healthful.
Choosing how much broccoli or broccoli sprouts to eat is really up to individual tolerance. Isothiocyanates are inherently bitter, and the human body naturally resists the intake of bitter foods. Aiming for 2 to 4 ounces of sprouts per day is a reasonable and healthy goal.
In this clip, Dr. Giselle Petzinger describes her recommended components for an exercise program for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses how no evidence exists that lifestyle factors, such as diet and exercise, can cure Parkinson's disease or obviate the need for dopamine replacement.
In this clip, Dr. Giselle Petzinger discusses how intense exercise can impact motor scores in people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger explains how to design an optimal exercise regimen for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger explains that strenuous exercise affects dopamine sensitivity in the brains of people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses how adding a cognitive load to an exercise program is important for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses the importance of incorporating intensity into the exercise routine for people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger describes the specific characteristics of exercise that make it so helpful to people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger describes how exercise may provide a repair model that allows some type of resilience against the insults of Parkinson's disease.
In this clip, Dr. Giselle Petzinger highlights some of the risk factors for Parkinson's disease, and discusses how this is likely a multifaceted problem.
In this clip, Dr. Giselle Petzinger explains how the loss of dopamine disrupts circuitry in the brains of people with Parkinson's disease.
In this clip, Dr. Giselle Petzinger discusses Parkinson's disease and explains how symptoms can vary dramatically between people.
In this clip, Dr. Rhonda Patrick describes the data suggesting that maternal supplemental vitamin D can reduce the risk of deficiency in breastfed infants.
In this clip, Dr. Rhonda Patrick explains why iron levels in breast milk are low.
In this clip, Dr. Rhonda Patrick describes the importance of vitamin K for newborn infants.
In this clip, Dr. Rhonda Patrick discusses the importance of omega-3 fatty acids in breast milk and their relevance for infant brain development.
In this clip, Dr. Rhonda Patrick describes the structure and function of milk fat globule membranes in breast milk.
In this clip, Dr. Rhonda Patrick describes the multifaceted roles of HMOs in breast milk.
In this episode, Dr. Rhonda Patrick describes the different types of fluids produced by the human breast during lactation and explains how the nutritional content of these fluids meet the infant's needs.
In this clip, Dr. Rhonda Patrick goes over harmful substances that can get into breastmilk and negatively affect an infant’s health.
In this clip, Dr. Rhonda Patrick discusses DHA bioavailability and describes her personal DHA regimen, which includes dietary and supplemental sources of omega-3 fatty acids.
In this clip, Dr. Rhonda Patrick describes the potential interaction between sulforaphane and iodine and stresses that iodine-deficient individuals or those with hypothyroidism should work with their physician to monitor thyroid hormone levels.
In this clip, Dr. Rhonda Patrick discusses the current sulforaphane research as it pertains to DNA damage, and highlights the importance of considering the different forms of studies.
In this clip, Dr. Rhonda Patrick describes advances in sulforaphane research that are particularly relevant to the brain.
In this clip, Dr. Rhonda Patrick describes the advantages and disadvantages of the various dietary and supplemental sources of sulforaphane.
In this clip, Dr. Rhonda Patrick explains that while magnesium L-threonate has yielded promising results in animal studies, this has yet to be translated to humans.
In this clip, Dr. Rhonda Patrick talks about the importance of obtaining adequate magnesium in the diet.
In this clip, Dr. Rhonda Patrick talks about the importance of obtaining adequate magnesium and describes her strategies, including her preferred dietary magnesium supplement.
In this clip, Dr. Rhonda Patrick discusses various sauna protocols that differ in temperature, timing, and frequency.
In this clip, Dr. Rhonda Patrick describes how the physiological effects observed during sauna use are comparable to those that occur during physical exercise.
In this clip, Dr. Rhonda Patrick discusses how heat can be used to increase muscle strength and counteract muscle wasting.
In this clip, Dr. Rhonda Patrick describes the effects of heat on mood, particularly in those experiencing depression.
In this clip, Dr. Rhonda Patrick discusses whether timing metformin administration apart from exercise may be a strategy to overcome some of its adverse effects.
In this clip, Dr. Rhonda Patrick describes the many open questions that remain regarding the interaction between metformin and exercise at the molecular level.
In this clip, Dr. Rhonda Patrick gives her thoughts on whether healthy, active adults should take metformin.
In this clip, Dr. Rhonda Patrick describes the relationship between metformin and cancer incidence and the relevance for those with type 2 diabetes.
In this Q&A clip, Rhonda discusses Quercetin, the impact of it's antiviral activity, and it's role as a zinc ionophore.
In this clip, Dr. Rhonda Patrick discusses whether COVID-19 disease causes permanent lung damage.
In this clip, Dr. Rhonda Patrick describes the effect of sex hormones on immune function.
In this clip, Dr. Rhonda Patrick describes the effect of sex hormones on immune function.
In this clip, Dr. Rhonda Patrick discusses how omega-3 fatty acids participate in resolving inflammation during an immune response.
In this clip, Dr. Rhonda Patrick discusses the trace element zinc and its role in the immune system.
In this clip, Dr. Rhonda Patrick describes how vitamin C is involved in immunity.
In this clip, Dr. Rhonda Patrick discusses how vitamin A is involved in mounting an immune response.
In this clip, Dr. Rhonda Patrick details the critical role that vitamin D plays in the immune response.
In this clip Dr. Rhonda Patrick discusses how deficiencies or insufficiencies in micronutrients might negatively affect immune function.
In this clip, Dr. Rhonda Patrick describes how varying levels of exercise affect the immune response in different ways.
In this clip, Dr. Rhonda Patrick explains how allergens in the environment may shape the immune system during early life.
In this clip, Dr. Rhonda Patrick describes how the body's microbiome affects immune function.
In this clip, Dr. Rhonda Patrick discusses how a lack of sleep impacts the immune response.
In this clip, Dr. Rhonda Patrick discusses how the quantity and quality of antibodies against a virus might lead to negative outcomes.
In this clip, Dr. Rhonda Patrick discusses the role that genetics plays in the immune system.
In this clip, Dr. Rhonda Patrick discusses the active area of investigation surrounding the immune response to the SARS-CoV-2 virus.
In this clip, Dr. Rhonda Patrick discusses the evidence surrounding how long the virus resides in the human body.
In this clip, Dr. Rhonda Patrick discusses what cross-immunity is and how it may be relevant for SARS-CoV-2.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the specifics of restoring a healthy microbiome using probiotics.
In this clip, Tim Ferriss describes his experience with Lyme disease, and how he used the ketogenic diet in conjunction with antibiotics to support his recovery.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the anti-cancer properties of the diabetes drug metformin.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the potential use of intravenous vitamin C as a supportive factor in the treatment of cancer.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss acute versus chronic inflammation and how supplemental antioxidants can negate some of the benefits of exercise.
In this clip, Tim Ferriss describes his efforts to mitigate the risk of Alzheimer's disease by managing his insulin levels using the ketogenic diet.
In this clip, Tim Ferriss discusses his MTHFR status and his experience with vitamin supplementation.
In this clip, Tim Ferriss outlines the biomarkers that he measures routinely to make sure his health is on-track while following a ketogenic diet
In this clip, Tim Ferriss describes the biomarkers that he tracks to fine-tune his health and mental well-being.
In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss vasopressin and its effects on pair bonding in both animals and humans.
In this clip, Dr. Dominic D'Agostino discusses the importance of an individualized approach when considering glutamine supplementation.
In this clip, Dr. Dominic D'Agostino describes how gluconeogenesis fills an important role during ketosis to maintain a basal level of glucose.
In this clip, Dr. Dominic D'Agostino explains how the periodic use of fasting and associated practices may provide health benefits.
In this clip, Dr. Dominic D'Agostino discusses the therapeutic effects of ketones on cancer growth.
In this clip, Dr. Dominic D'Agostino discusses the neuroprotective potential associated with a combination of ketones and lactate in the management of traumatic brain injury.
In this clip, Dr. Dominic D'Agostino describes the positive effects that ketones can have on the brain.
In this clip, Dr. Dominic D'Agostino discusses the metabolic flexibility of the brain to use various substrates, including ketones, for energy.
In this clip, Dr. Dominic D'Agostino explains the interrelationship between ketones and lactate as sources of energy for the brain and the role ketones may have in reducing oxidative stress through greater energetic efficiency.
In this clip, Dr. Dominic D'Agostino discusses how the body adapts to a ketogenic diet and the possible impacts on age-related chronic diseases.
In this clip, Dr. Dominic D'Agostino describes the benefits of including fiber from diverse vegetable sources, both cooked and raw, within a ketogenic diet plan.
In this clip, Dr. Dominic D'Agostino and Dr. Rhonda Patrick discuss the ketogenic diet and its implications for gut health.
In this clip, Dr. Dominic D'Agostino describes different approaches that allow the ketogenic diet to be more accessible.
In this clip, Dr. Dominic D'Agostino describes the parameters that affect an individual's response to ketosis.
In this clip, Dr. Dominic D'Agostino describes his research into the role of ketosis and ketone supplements in stabilizing brain energy metabolism.
Maintaining a healthy vitamin D status, an imminently solvable but often ignored problem, may turn out to be an important factor in protecting against susceptibility to lung injury in COVID-19.
In this clip, Wim Hof shares his personal story that led to his passionate pursuit of how we can harness the body's innate ability to heal itself.
In this clip, Wim Hof describes the experiment in which scientists first discovered that his techniques were having a physiologically unexpected effect.
In this clip, Wim Hof and Dr. Rhonda Patrick discuss how cold shock and controlled breathing techniques may be used to treat conditions including depression, obsessive-compulsive disorder, and anxiety.
In this clip, Wim Hof discusses how his breathing techniques calm the mind and allow practitioners to access the parasympathetic system more immediately.
In this clip, Wim Hof describes how his breathing techniques affect the immune response and its potential use in combating disease.
In this clip, Wim Hof discusses how his breathing techniques may allow the body to tap into its natural disease-fighting abilities.
In this clip, Wim Hof describes how his breathing methods impact blood levels and can modify the body's response to pain.
In this clip, Wim Hof discusses how his breathing techniques can affect the body's pH level, yielding potential health benefits.
In this clip, Wim Hof describes how he controls his breath to deal with the discomfort of the cold.
In this clip, Wim Hof gives us some insight into how his fascination with the cold originally began.
In this clip, Dr. Ray Cronise emphasizes the importance of diet to improve healthspan rather than employing tricks to boost metabolic rate.
In this clip, Dr. Ray Cronise discusses his approach to choosing a diet to optimize healthspan.
In this clip, Dr. Ray Cronise and Dr. Rhonda Patrick discuss the importance of diet in maximizing healthspan and longevity.
In this clip, Dr. Ray Cronise shares his personal experiences with cold stress and weight loss.
In this clip, Dr. Peter Attia describes the potential use of lactate or beta-hydroxybutyrate in the treatment of traumatic brain injury.
In this clip, Dr. Peter Attia stresses the further risks of head trauma for those with the APOE4 gene variant.
In this clip, Dr. Peter Attia and Dr. Rhonda Patrick examine the use of various fuel sources in brain metabolism.
In this clip, Dr. Peter Attia addresses the challenges of balancing IGF-1 levels in the brain and body to promote neurogenesis without stimulating cancer.
In this clip, Dr. Peter Attia explains his position on the relationship between insulin resistance and Alzheimer’s disease risk.
In this clip, Dr. Peter Attia outlines the relative risk and biomarkers associated with some of the leading human diseases.
In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss the unique dietary and lifestyle considerations for carriers of the APOE4 gene variant.
In this clip, Dr. Peter Attia discusses the role of the APOE4 gene variant and the associated risk for Alzheimer’s disease and cardiovascular disease.
In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss how a healthy digestive tract interacts with the immune system to curb inflammation.
In this clip, Dr. Peter Attia describes his empirical strategy to obtain a personalized nutrition plan for longevity.
In this clip, Dr. Peter Attia explains the complex relationship that exists between cancer cells, the immune system, and IGF-1.
In this clip, Dr. Peter Attia explains the importance of the amino acid leucine and its role in the mTOR pathway.
In this clip, Dr. Peter Attia explains the interrelated mTOR and IGF-1 growth pathways and the delicate balance required to limit accelerated aging.
In this clip, Dr. Peter Attia explains the challenges involved in studying how diet and lifestyle affect longevity in humans.
Dr. Jed Fahey describes a study that demonstrated sulforaphane's chemoprotective qualities against benzene exposure.
Dr. Jed Fahey discusses the potential therapeutic benefit of sulforaphane in treating depression.
Dr. Jed Fahey describes the health benefits associated with moringin and discusses the chemical structure differences between it and sulforaphane.
Dr. Fahey describes the metabolic fate of sulforaphane and the current state of research on its effects against bladder cancer.
Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and the time frame required for full conversion.
Dr. Jed Fahey describes the effects of freezing and freeze-drying of broccoli sprouts on sulforaphane production.
Dr. Jed Fahey describes factors that influence isothiocyanate production.
Dr. Jed Fahey discusses the beneficial effects broccoli sprouts have in mediating the harmful effects of _H. pylori_.
Dr. Jed Fahey describes the beneficial effects of sulforaphane in modulating the symptoms of autism and other brain disorders.
Dr. Jed Fahey describes the current state of the science of understanding how sulforaphane influences longevity.
Drs. Jed Fahey and Rhonda Patrick discuss concerns about the safety and efficacy of probiotic supplements.
Dr. Jed Fahey discusses the importance of having active myrosinase in dietary supplements for optimizing the conversion of glucoraphanin to sulforaphane.
Dr. Jed Fahey discusses concerns about the sulforaphane dietary supplement industry and offers advice about how to choose quality products.
Dr. Jed Fahey describes some of the factors that influence the conversion of myrosinase-driven conversion of glucoraphanin to sulforaphane.
Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and cautions against preparation techniques that might inhibit their production.
Dr. Jed Fahey describes how sulforaphane was discovered, how it is produced in plants, and the mechanisms by which it produces health effects in humans.
Dr. Jed Fahey describes the early co-discoveries of sulforaphane and Nrf2, and describes the importance of the Nrf2 pathway.
In this clip, Dr. Erica Sonnenburg describes the important role of human milk oligosaccharides in establishing a healthy gut in an infant.
In this clip, Dr. David Sinclair elaborates on his Informational Theory of Aging.
In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with NAD+ boosters.
In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol.
In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol and NAD+ boosters.
In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.
In this clip, Dr. David Sinclair describes his personal sleep habits for optimal performance during his workday.
In this clip, Dr. Rhonda Patrick describes her personal experience with sleep deprivation and her subsequent altered metabolism.
In this clip, Dr. David Sinclair describes his personal resveratrol and nicotinamide mononucleotide supplementation habits.
In this clip, Dr. David Sinclair discusses the economic issues associated with research using nicotinamide riboside and nicotinamide mononucleotide.
In this clip, Dr. David Sinclair discusses the current state of research on nicotinamide mononucleotide.
In this clip, Dr. David Sinclair discusses the stability issues encountered with nicotinamide riboside and nicotinamide mononucleotide.
In this clip, Dr. David Sinclair discusses the current state of research on the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide.
In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.
In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.
In this clip, Dr. David Sinclair describes research demonstrating the beneficial effects of resveratrol on the cardiovascular system of monkeys.
In this clip, Dr. David Sinclair describes how plant-based compounds activate cellular protective mechanisms in humans.
In this clip, Dr. David Sinclair describes the NAD+ salvage pathway and how boosting cellular NAD+ levels may be beneficial in slowing aging.
In this clip, Dr. Rhonda Patrick describes a study in which stem cell-derived retinal cells were used to treat macular degeneration in a human.
In this clip, Dr. David Sinclair talks about the discovery of genes that can reset the Horvath epigenetic clock.
In this clip, Dr. David Sinclair describes how epigenomic modifications can influence how an organism ages, potentially reversing years of age-related damage.
In this clip, Dr. David Sinclair explains why NAD+ levels decrease with age.
In this clip, Dr. David Sinclair describes the links between NAD+, sirtuins, and resveratrol in the aging process.
In this clip, Dr. David Sinclair describes the role of NAD+ in the regulation of the body's circadian clock and sirtuin production.
In this clip, Dr. David Sinclair describes how sirtuins, caloric restriction, fasting, and the insulin-IGF-1 pathway converge to modulate aging and lifespan.
In this clip, Dr. David Sinclair describes the major breakthroughs in aging research and the unique relationships that develop between researchers and the organisms they study.
In this clip, Dr. Valter Longo describes the origins of the fasting-mimicking diet and explains how it enhances chemotherapeutic treatments.
In this clip, Dr. Roland Griffiths describes the current state of research on psychedelic drugs.
In this clip, Dr. Charles Raison describes the complex relationship between inflammation and depression.
In this clip, Dr. Roland Griffiths discusses the potential uses, challenges, and risks associated with gaining FDA approval for psilocybin use as a therapeutic treatment.
In this clip, Dr. Valter Longo describes the IGF-1 pathway and explains how defects in the pathway influence disease risk.
In this clip, Dr. Roland Griffiths describes the current state of research on long-term meditation and the role psilocybin plays in that research.
In this clip, Dr. Roland Griffiths discusses the reorganizational effects that psychedelic experiences have on the brain and their potential use in treating mental disorders.
In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the sociocultural aspects of hallucinogenic substance use.
In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the effects of meditation on gene expression.
In this clip, Dr. Roland Griffiths discusses similarities in the effects of psilocybin and meditation on the brain and their potential usefulness in treating depression.
In this clip, Dr. Rhonda Patrick describes how sauna use activates the Salvinorin A pathway, potentially ameliorating symptoms of depression and opioid addiction.
In this clip, Dr. Roland Griffiths describes new findings that suggest psilocybin may be useful in managing the symptoms of treatment-resistant depression.
Dr. Valter Longo defines the different fasting modalities, and compares and contrasts the variations of each in duration and degree of restrictiveness.
Dr. Valter Longo explains how certain macronutrients influence the insulin/IGF-1/growth hormone axis to modulate aging in many cell types.
Dr. Valter Longo discusses how the fasting-mimicking diet nourishes patients while still activating some of the same metabolic responses as a water-only fast.
Dr. Valter Longo describes how fasting and the ketogenic diet used together with the standard of care treatment may help treat aggressive cancers.
Dr. Valter Longo explains why clinical trials of the fasting-mimicking diet in combination with standard cancer treatments have been slow to progress.
Dr. Longo describes the promising research that suggests that one's risk for diseases over the next 10 years may be drastically reduced.
Dr. Valter Longo discusses how the fasting-mimicking diet is one of the few dietary interventions that can increase relative lean body mass.
Dr. Longo discusses his work that indicates that the fasting-mimicking diet holds promise for the treatment of autoimmune diseases, particularly multiple sclerosis.
Dr. Valter Longo describes the pivotal role that IGF-1 plays in the proliferation of stem cells and the importance of consuming sufficient protein.
Dr. Valter Longo highlights which biomarkers, both currently available and forthcoming, that he considers relevant when assessing longevity and biological age.
Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.
Dr. Valter Longo explains how frequently the fasting-mimicking diet can be practiced and his hope that it may support sustained weight loss.
Dr. Valter Longo discusses his new book "The Longevity Diet" and how his fasting-mimicking diet can treat or prevent several age-related diseases.
Dr. Charles Raison discusses his belief that ancient practices are more likely than modern pharmacology to encourage resilience and stave off depression.
Dr. Charles Raison explains how agents that interact with the immune system may play a subtle and complex role in depression.
Dr. Charles Raison discusses how a pro-inflammatory environment, such as that which occurs with obesity, can contribute to the risk of depression.
Dr. Charles Raison describes the convergence of data that is directing scientists to uncover the connection that exists between inflammation and depression.
Dr. Charles Raison describes the Wild 5 trackable wellness intervention and how it may be incorporated into the treatment of depression.
Dr. Charles Raison discusses how exposure to light during the day and maintaining a dark environment at night, is important in depression management.
Dr. Charles Raison describes how changes in time zones or sleep/wake patterns can be a stressor for individuals with bipolar disorder.
Dr. Charles Raison and Dr. Rhonda Patrick discuss the potential benefits of meditation and running to improve mood.
Dr. Charles Raison describes how the body has evolved to employ some of the same physiological mechanisms in depression and physical illnesses.
Dr. Charles Raison describes strategies that have evolved to offset the risks associated with eating, such as inflammation and the antibiotic effects of hyperthermia.
Dr. Charles Raison describes how whole-body hyperthermia has the potential for real-world clinical efficacy as a tool in the fight against major depression.
Dr. Charles Raison explains that taking non-steroidal anti-inflammatory agents or high dose antioxidants may block some of the benefits of exercise.
Dr. Charles Raison explains the relationship between thermoregulatory dysfunction and how periodic exposure to high heat may aid with treating depression and schizophrenia.
Dr. Charles Raison highlights how ancient practices such as heat exposure, long-distance running and fasting may promote well-being in the modern world.
Dr. Charles Raison discusses how psychedelic substances like psilocybin, which induce transcendent trance-like states may be useful in the treatment of depression.
Dr. Elissa Epel discusses potential concerns about supplementation and describes some of the studies that demonstrate the links between healthy lifestyle behaviors.
Dr. Elissa Epel identifies several biohacks that show promise as strategies to reduce stress and lengthen telomeres.
Dr. Rhonda Patrick describes the effects of endogenous ketones on fat metabolism during a fast.
Dr. Rhonda Patrick provides advice on how to break a fast.
Dr. Rhonda Patrick discusses when electrolyte replenishment might be necessary.
Dr. Rhonda Patrick describes the dual nature of biochemical pathways involved in aging and explains how exercise tips the balance toward its beneficial properties.
Dr. Rhonda Patrick discusses the circumstances under which eating prior to exercise is beneficial versus detrimental.
Dr. Rhonda Patrick describes some of the different types of fasting and identifies the advantages associated with each.
Dr. Rhonda Patrick discusses the pros and cons of consuming black coffee and amino acids during fasting.
Dr. Jari Laukkanen discusses the benefits and risks associated with cold water immersion following sauna use.
Drs. Rhonda Patrick and Jari Laukkanen discuss the benefits of sauna use in terms of cardiorespiratory fitness and mood.
Drs. Rhonda Patrick and Jari Laukkanen discuss the advantages of sauna use post-exercise.
Dr. Rhonda Patrick describes the role that heat shock proteins play in reducing the risk of disease.
Dr. Jari Laukkanen discusses the optimal temperature and amount of time for sauna use to obtain the greatest health benefits.
Dr. Jari Laukkanen describes some of the mechanisms that drive healthy blood pressure among men who use the sauna regularly.
Drs. Rhonda Patrick and Jari Laukkanen discuss findings from a study linking sauna use and lower risk of death from cardiovascular disease.
Dr. Eric Verdin describes the liver's functions and proposes that the ketogenic diet does not put any undue stress on the liver.
Dr. Eric Verdin discusses several ways in which NAD+ supplementation can benefit mitochondrial health and play a protective role against aging.
Dr. Eric Verdin explains how nicotinamide adenine dinucleotide levels diminish with age along with the ongoing research to understand the reasons why.
Dr. Eric Verdin describes the emerging field of biomarkers of aging and the diverse strategies, including artificial intellegence, that are being employed.
Dr. Eric Verdin discusses the idea that increasing protein levels too high while on a ketogenic diet may have adverse health effects.
Dr. Eric Verdin describes how supplementing with exogenous ketone esters may confer some of the beneficial effects of the ketogenic diet.
Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.
Dr. Eric Verdin explains how a cyclic or the portion-controlled ketogenic diet is linked to improvements in lifespan and memory in mice.
Dr. Eric Verdin describes how fasting or a fasting-mimicking diet can influence healthspan and lifespan including discussion of some of the potential mechanisms.
Dr. Eric Verdin explains the importance of the insulin signaling pathway in aging and highlights both animal and human research in this area.
Dr. Eric Verdin explains how exercise and nutrition form the cornerstone of strategies to slow aging, but exciting approaches are ahead.
Dr. Valter Longo discusses the longevity-conferring effects of diminishing the pro-aging IGF-1 pathway.
Dr. Valter Longo discusses how autophagy may function in both normal and cancer cells.
Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.
Dr. Valter Longo discusses the origin of the fasting-mimicking diet and a possible shift from a drug-centered mentality to one which allows the body to heal itself.
Dr. Valter Longo describes how fasting may reduce the toxicity of chemotherapeutic drugs while also maximizing their impact in the treatment of cancer.
Dr. Valter Longo describes how fasting promotes the immune system to return to a more youthful profile.
Dr. Valter Longo describes how the fasting-mimicking diet can be beneficial in the treatment of various diseases, including multiple sclerosis.
Dr. Valter Longo explains how fatty acid usage by cancer cells weakens them and makes them more susceptible to immune system clearance.
Dr. Valter Longo describes how a fasting-mimicking diet can be used for fat loss while preserving lean muscle mass.
Dr. Valter Longo explains the difference between caloric restriction and periodic fasting and highlights the importance of refeeding after a fast.
Dr. Valter Longo discusses how fasting can play a role in the activation and renewal of stem cells by altering the metabolic profile.
Dr. Valter Longo describes how a fasting-mimicking diet can reduce markers of inflammation, resetting our biological systems to a more youthful state.
Dr. Valter Longo describes how prolonged fasting and subsequent refeeding, sends signals to the body to systematically shrink and rebuild organ systems.
Dr. Valter Longo explains the benefits of a prolonged fast.
Dr. Valter Longo describes his approach to fasting and his philosophy that if an eating protocol is too regimented people will abandon it.
Dr. Guido Kroemer describes mitophagy, a cellular signal for mitochondrial biogenesis, and a key player in other physiological processes.
Dr. Guido Kroemer describes the cellular process of autophagy and what factors trigger its activation.
Dr. Guido Kroemer describes how mitophagy contributes to the pathophysiology of neurodegenerative disease and how autophagy might mitigate these processes.
Dr. Guido Kroemer describes how fasting associated with sickness behavior is critical to surviving infection.
Dr. Guido Kroemer describes the complex relationship that exists between cancer cells, the immune system, and autophagy.
Dr. Guido Kroemer discusses changes that occur within cells that signal the need to induce autophagy.
Dr. Guido Kroemer describes the anti-diabetes and anti-obesity effects of exercise-induced autophagy.
Dr. Guido Kroemer describes the interplay between protein deacetylation and autophagy.
Dr. Guido Kroemer describes how intermittent fasting recapitulates the life-extension benefits of caloric restriction without some of the drawbacks.
Dr. Guido Kroemer discusses the autophagy-inducing qualities of coffee.
Dr. Guido Kroemer describes the autophagy-inducing behaviors he practices as part of his healthy lifestyle.
Dr. Guido Kroemer describes the autophagy-inducing effects of calorie restriction mimetics such as spermidine and resveratrol.
Dr. Guido Kroemer describes the spectacular biological phenomenon known as autophagy.
Dr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans.
Dr. Satchin Panda describes the beneficial effects of time-restricted feeding in mice in terms of mitochondrial health.
Dr. Satchin Panda explains the role of the suprachiasmatic nucleus – the body's master clock – and how it affects metabolism.
Dr. Satchin Panda describes CLOCK's varied response to light and food and how those responses affect metabolism.
In this clip, Dr. Satchin Panda describes how lifestyle factors influence the risk of heart arrhythmias.
In this clip, Dr. Satchin Panda describes the effects of inappropriate light signals and discusses strategies to mitigate their effects.
Dr. Satchin Panda describes how the body's circadian clocks developed and the role they play in regulating our day-to-day functioning.
Dr. Rhonda Patrick describes how bright light exposure drives cortisol release.
Dr. Satchin Panda describes how time-restricted eating lessens the symptoms of acid reflux in people who practice time-restricted eating.
In this clip, Dr. Satchin Panda describes experiments in which time-restricted eating protected mice from the harms of an obesogenic diet.
Dr. Satchin Panda describes some of the challenges associated with studying the effects of shift work and how time-restricted eating might benefit those who work shifts.
Dr. Satchin Panda explains the ideas behind MyCircadianClock and how it is helping the research surrounding time-restricted eating.
Dr. Satchin Panda describes the maturation schedule of the body's circadian clocks and makes recommendations about when to start time-restricted eating in children.
Dr. Satchin Panda describes how circadian rhythms influence DNA damage and repair, especially in the setting of time-restricted eating
Dr. Satchin Panda explains the physiological response to food and why eating less often while practicing time-restricted eating might have even greater health benefits.
Dr. Satchin Panda describes his take on what "healthy" means from a circadian perspective and how time-restricted eating plays a part.
Dr. Satchin Panda describes recent research that links melatonin to metabolism and explains how time-restricted eating can capitalize on this link.
Dr. Satchin Panda describes the role fasting plays in maintaining a healthy gut and reducing systemic inflammation.
Dr. Satchin Panda discusses the limited data available today regarding dietary supplement usage, exercise, and time-restricted eating.
Dr. Satchin Panda quells concerns that toothpaste might start the circadian clock.
Dr. Satchin Panda describes how autophagy, as part of the body's response to time-restricted eating, benefits health on a daily basis.
Dr. Satchin Panda describes the state of the science with regard to understanding the beneficial effects of time-restricted eating in humans.
Dr. Satchin Panda explains how time-restricted eating realigns the primordial rhythms of our physiology, allowing us to repair and rejuvenate our bodies.
Dr. Satchin Panda discusses when to break a fast and describes how time-restricted eating can be a healthy lifestyle behavior for nearly everyone.
Dr. Satchin Panda discusses the controversy surrounding consumption of black coffee or tea while practicing time-restricted eating.
Dr. Dale Bredesen identifies the defining characteristics of Alzheimer’s disease and enumerates its known subtypes.
Dr. Dale Bredesen describes the risks associated with APOE4 and identifies strategies for mitigating that risk.
Dr. Dale Bredesen discusses strategies for identifying factors that contribute to one's risk of developing Alzheimer's disease and describes strategies for mitigating that risk.
Dr. Dale Bredesen describes the role that zinc status plays in the development of the toxic form of Alzheimer's disease.
Dr. Dale Bredesen describes his novel dietary protocol, the Ketoflex 12/3, and how it improves cognitive function.
Dr. Dale Bredesen describes the links between pathogen exposure and Alzheimer's disease.
Dr. Dale Bredesen describes how sauna use is now being used as a means to reduce the body's overall toxic burden.
Dr. Dale Bredesen discusses the potential brain-health benefits associated with a ketogenic diet.
Dr. Matthew Walker describes how studies in rats and humans demonstrate that the brain "replays" events and experiences to facilitate learning.
Dr. Matthew Walker describes how sleep impairs the opposing actions of the amygdala and prefrontal cortex to influence mood and mental health.
Dr. Matthew Walker describes how sound and smell cues played during learning and subsequent sleep can enhance memory formation and retrieval.
Dr. Matthew Walker explains how altering light-dark schedules can improve health outcomes in older adults and babies.
Dr. Matthew Walker talks about the importance of identifying early-life windows of vulnerability to prevent or delay age-related cognitive decline.
Dr. Matthew Walker describes how napping facilitates and reinforces learning in infants.
Dr. Matthew Walker describes how REM sleep facilitates creativity, new ideas, and wisdom.
Dr. Matthew Walker describes how sleep deprivation promotes a kind of "viral" loneliness.
Dr. Matthew Walker describes the deleterious effects that poor sleep has on the immune system.
Dr. Matthew Walker describes the risks associated with sleeping pill use and the benefits of cognitive behavioral therapy as an alternative treatment for sleep problems.
Dr. Matthew Walker describes the four essential pillars of sleep.
Dr. Matthew Walker describes how sleep deprivation drives a preferential desire for high carbohydrate foods.
Dr. Matthew Walker discusses the role that sleep plays in modulating the gut microbiome.
Dr. Matthew Walker describes the role that sleep plays in learning and new memory formation.
Dr. Matthew Walker posits his theory that dreams are not forgotten; rather, they are merely inaccessible and may influence our wakeful state.
Dr. Matthew Walker discusses how anxiety affects sleep and identifies ways to manage that stress to improve sleep.
Dr. Matthew Walker explains how sleep and sauna may induce sleep through their short-term pro-inflammatory effects.
Dr. Matthew Walker describes the negative effects of blue light exposure on melatonin production and sleep.
Dr. Matthew Walker explains how sleep deprivation impairs glucose metabolism, increasing the risk of diabetes and metabolic dysfunction.
Dr. Matthew Walker describes the dual risk of carrying the APOE4 allele and having sleep apnea.
Dr. Matthew Walker describes the different chronotypes and the risks associated with adopting a sleep pattern that is contrary to our natural type.
Dr. Matthew Walker describes the role that sleep plays in modulating the accumulation of amyloid-beta accumulation in the brain.
Dr. Matthew Walker describes critical factors that influence healthy sleep patterns, including the intake of caffeine, alcohol, and other substances.
Dr. Matthew Walker describes how the different stages of sleep influence emotional and cardiovascular health.
Dr. Matthew Walker discusses the harmful effects of sleeping pills on learning and memory formation.
Dr. Matthew Walker describes the role of temperature in augmenting sleep.
Dr. Matthew Walker explains how altering the timing and duration of daytime light exposure influences sleep.
Dr. Ruth Patterson describes how obesity - along with the growth factors estrogen and insulin - affect the risk of breast cancer development and recurrence.
Dr. Ruth Patterson discusses how skipping breakfast and eating late into the evening may contribute to worse metabolic health.
Dr. Ruth Patterson discusses how simply changing when one eats can have a profound effect on the risk of breast cancer recurrence.
Dr. Ruth Patterson describes the advantages of an earlier eating window on inflammation and blood glucose control.
In this clip, Dr. Ruth Patterson discusses the effect that meal frequency has on breast cancer risk.
In this clip, Dr. Ruth Patterson discusses how eating in accordance with the body's natural circadian rhythm may reduce the risk of breast cancer.
Dr. Ruth Patterson describes how eating following the body's circadian clock enables the body to focus on repair rather than on digestion.
Dr. Ruth Patterson discusses how healthful choices, such as even modest weight loss, can have beneficial effects that reduce the risk of breast cancer and a variety of other diseases
Dr. Ruth Patterson discusses the beneficial effects that time-restricted eating can have on the biomarkers of health - independent of weight loss.
Dr. Patterson explains how a lifestyle approach - an altered eating window - can be an effective way to reduce blood sugar levels.
Dr. Elissa Epel describes how pre-pregnancy parental health impacts offspring.
Dr. Elissa Epel describes the effects of longer sperm telomere length on subsequent generations.
Dr. Rhonda Patrick and Dr. Elissa Epel describe the factors that influence how we respond to diet.
Dr. Elissa Epel describes how even small lifestyle changes can have an effect on telomere length and healthy aging to compress morbidity.
Dr. Rhonda Patrick and Dr. Elissa Epel discuss how obesity affects genes in sperm DNA involved in metabolic health and cognitive function.
Dr. Elissa Epel discusses the pros and cons associated with taking dietary supplements to lengthen telomeres.
Dr. Elissa Epel discusses how cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal.
Dr. Elissa Epel discusses the harmful effects of what she calls a "toxic lifestyle," one that includes the consumption of sugar-sweetened beverages.
Dr. Elissa Epel describes some of the studies that demonstrate the links between healthy lifestyle behaviors like exercise and discusses potential mechanisms.
Dr. Elissa Epel describes the "low hanging fruit" – small, healthy lifestyle behaviors – that can have positive effects on telomere length and lifespan.
Dr. Elissa Epel identifies some of the key differences in male and female biology and how they influence telomere length and aging.
Dr. Elissa Epel gives a brief overview of telomeres and the enzyme telomerase and explains how they impact health and lifespan.
Dr. Elissa Epel discusses the importance of having an optimal ratio of telomerase to reduce the risk of chronic diseases and cancer.
Dr. Elissa Epel explains how aging syndromes can be passed to offspring via epigenetic mechanisms.
Dr. Elissa Epel describes how Mendelian randomization techniques provide insights into the dual nature of telomeres, as both a cause and a sign of aging.
Dr. Elissa Epel describes the exposome – the totality of non-genetic exposures a person experiences during a lifetime – and explains how it affects telomeres.
Dr. Elissa Epel describes how toxic stress modulates telomere length.
Dr. Elissa Epel describes the beneficial effects of education on telomere length in the babies of low-income women.
Dr. Elissa Epel describes the non-linear effects of exercise on telomere length.
Dr. Rhonda Patrick speaks with Dr. Bruce Ames, about a micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that was developed in the Ames laboratory.