Episode archive

Posted on June 1st 2020 (about 13 hours)

In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss the potential use of intravenous vitamin C as a supportive factor in the treatment of cancer.

Posted on June 1st 2020 (about 14 hours)

In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss acute versus chronic inflammation and how supplemental antioxidants can negate some of the benefits of exercise.

Posted on June 1st 2020 (about 14 hours)

In this clip, Tim Ferriss describes his efforts to mitigate the risk of Alzheimer's disease by managing his insulin levels using the ketogenic diet.

Posted on June 1st 2020 (about 14 hours)

In this clip, Tim Ferriss discusses his MTHFR status and his experience with vitamin supplementation.

Posted on June 1st 2020 (about 15 hours)

In this clip, Tim Ferriss outlines the biomarkers that he measures routinely to make sure his health is on-track while following a ketogenic diet

Posted on June 1st 2020 (about 15 hours)

In this clip, Tim Ferriss describes the biomarkers that he tracks to fine-tune his health and mental well-being.

Posted on June 1st 2020 (about 15 hours)

In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss vasopressin and its effects on pair bonding in both animals and humans.

Posted on May 26th 2020 (7 days)

In this clip, Dr. Dominic D'Agostino discusses the importance of an individualized approach when considering glutamine supplementation.

Posted on May 26th 2020 (7 days)

In this clip, Dr. Dominic D'Agostino describes how gluconeogenesis fills an important role during ketosis to maintain a basal level of glucose.

Posted on May 26th 2020 (7 days)

In this clip, Dr. Dominic D'Agostino explains how the periodic use of fasting and associated practices may provide health benefits.

Posted on May 26th 2020 (7 days)

In this clip, Dr. Dominic D'Agostino discusses the therapeutic effects of ketones on cancer growth.

Posted on May 26th 2020 (7 days)

In this clip, Dr. Dominic D'Agostino discusses the neuroprotective potential associated with a combination of ketones and lactate in the management of traumatic brain injury.

Posted on May 26th 2020 (7 days)

In this clip, Dr. Dominic D'Agostino describes the positive effects that ketones can have on the brain.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino discusses the metabolic flexibility of the brain to use various substrates, including ketones, for energy.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino explains the interrelationship between ketones and lactate as sources of energy for the brain and the role ketones may have in reducing oxidative stress through greater energetic efficiency.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino discusses how the body adapts to a ketogenic diet and the possible impacts on age-related chronic diseases.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino describes the benefits of including fiber from diverse vegetable sources, both cooked and raw, within a ketogenic diet plan.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino and Dr. Rhonda Patrick discuss the ketogenic diet and its implications for gut health.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino describes different approaches that allow the ketogenic diet to be more accessible.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino describes the parameters that affect an individual's response to ketosis.

Posted on May 25th 2020 (8 days)

In this clip, Dr. Dominic D'Agostino describes his research into the role of ketosis and ketone supplements in stabilizing brain energy metabolism.

Posted on April 19th 2020 (about 1 month)

Maintaining a healthy vitamin D status, an imminently solvable but often ignored problem, may turn out to be an important factor in protecting against susceptibility to lung injury in COVID-19.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof shares his personal story that led to his passionate pursuit of how we can harness the body's innate ability to heal itself.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof describes the experiment in which scientists first discovered that his techniques were having a physiologically unexpected effect.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof and Dr. Rhonda Patrick discuss how cold shock and controlled breathing techniques may be used to treat conditions including depression, obsessive-compulsive disorder, and anxiety.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof discusses how his breathing techniques calm the mind and allow practitioners to access the parasympathetic system more immediately.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof describes how his breathing techniques affect the immune response and its potential use in combating disease.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof discusses how his breathing techniques may allow the body to tap into its natural disease-fighting abilities.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof describes how his breathing methods impact blood levels and can modify the body's response to pain.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof discusses how his breathing techniques can affect the body's pH level, yielding potential health benefits.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof describes how he controls his breath to deal with the discomfort of the cold.

Posted on February 28th 2020 (3 months)

In this clip, Wim Hof gives us some insight into how his fascination with the cold originally began.

Posted on February 28th 2020 (3 months)

In this clip, Dr. Ray Cronise emphasizes the importance of diet to improve healthspan rather than employing tricks to boost metabolic rate.

Posted on February 28th 2020 (3 months)

In this clip, Dr. Ray Cronise discusses his approach to choosing a diet to optimize healthspan.

Posted on February 28th 2020 (3 months)

In this clip, Dr. Ray Cronise and Dr. Rhonda Patrick discuss the importance of diet in maximizing healthspan and longevity.

Posted on February 28th 2020 (3 months)

In this clip, Dr. Ray Cronise shares his personal experiences with cold stress and weight loss.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia describes the potential use of lactate or beta-hydroxybutyrate in the treatment of traumatic brain injury.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia stresses the further risks of head trauma for those with the APOE4 gene variant.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia and Dr. Rhonda Patrick examine the use of various fuel sources in brain metabolism.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia addresses the challenges of balancing IGF-1 levels in the brain and body to promote neurogenesis without stimulating cancer.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia explains his position on the relationship between insulin resistance and Alzheimer’s disease risk.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia outlines the relative risk and biomarkers associated with some of the leading human diseases.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss the unique dietary and lifestyle considerations for carriers of the APOE4 gene variant.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia discusses the role of the APOE4 gene variant and the associated risk for Alzheimer’s disease and cardiovascular disease.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia and Dr. Rhonda Patrick discuss how a healthy digestive tract interacts with the immune system to curb inflammation.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia describes his empirical strategy to obtain a personalized nutrition plan for longevity.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia explains the complex relationship that exists between cancer cells, the immune system, and IGF-1.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia explains the importance of the amino acid leucine and its role in the mTOR pathway.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia explains the interrelated mTOR and IGF-1 growth pathways and the delicate balance required to limit accelerated aging.

Posted on February 11th 2020 (4 months)

In this clip, Dr. Peter Attia explains the challenges involved in studying how diet and lifestyle affect longevity in humans.

Posted on January 30th 2020 (4 months)

Dr. Jed Fahey describes a study that demonstrated sulforaphane's chemoprotective qualities against benzene exposure.

Posted on January 27th 2020 (4 months)

Dr. Jed Fahey discusses the potential therapeutic benefit of sulforaphane in treating depression.

Posted on January 27th 2020 (4 months)

Dr. Jed Fahey describes the health benefits associated with moringin and discusses the chemical structure differences between it and sulforaphane.

Posted on January 27th 2020 (4 months)

Dr. Fahey describes the metabolic fate of sulforaphane and the current state of research on its effects against bladder cancer.

Posted on January 27th 2020 (4 months)

Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and the time frame required for full conversion.

Posted on January 26th 2020 (4 months)

Dr. Jed Fahey describes the effects of freezing and freeze-drying of broccoli sprouts on sulforaphane production.

Posted on January 26th 2020 (4 months)

Dr. Jed Fahey describes factors that influence isothiocyanate production.

Posted on January 26th 2020 (4 months)

Dr. Jed Fahey discusses the beneficial effects broccoli sprouts have in mediating the harmful effects of _H. pylori_.

Posted on January 26th 2020 (4 months)

Dr. Jed Fahey describes the beneficial effects of sulforaphane in modulating the symptoms of autism and other brain disorders.

Posted on January 26th 2020 (4 months)

Dr. Jed Fahey describes the current state of the science of understanding how sulforaphane influences longevity.

Posted on January 26th 2020 (4 months)

Drs. Jed Fahey and Rhonda Patrick discuss concerns about the safety and efficacy of probiotic supplements.

Posted on January 26th 2020 (4 months)

Dr. Jed Fahey discusses the importance of having active myrosinase in dietary supplements for optimizing the conversion of glucoraphanin to sulforaphane.

Posted on January 20th 2020 (4 months)

Dr. Jed Fahey discusses concerns about the sulforaphane dietary supplement industry and offers advice about how to choose quality products.

Posted on January 20th 2020 (4 months)

Dr. Jed Fahey describes some of the factors that influence the conversion of myrosinase-driven conversion of glucoraphanin to sulforaphane.

Posted on January 20th 2020 (4 months)

Dr. Jed Fahey describes the chemical reaction that produces isothiocyanates and cautions against preparation techniques that might inhibit their production.

Posted on January 17th 2020 (5 months)

Dr. Jed Fahey describes how sulforaphane was discovered, how it is produced in plants, and the mechanisms by which it produces health effects in humans.

Posted on January 17th 2020 (5 months)

Dr. Jed Fahey describes the early co-discoveries of sulforaphane and Nrf2, and describes the importance of the Nrf2 pathway.

Posted on November 22nd 2019 (6 months)

In this clip, Dr. Erica Sonnenburg describes the important role of human milk oligosaccharides in establishing a healthy gut in an infant.

Posted on November 8th 2019 (7 months)

In this clip, Dr. David Sinclair elaborates on his Informational Theory of Aging.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with NAD+ boosters.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol and NAD+ boosters.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes his personal sleep habits for optimal performance during his workday.

Posted on November 7th 2019 (7 months)

In this clip, Dr. Rhonda Patrick describes her personal experience with sleep deprivation and her subsequent altered metabolism.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes his personal resveratrol and nicotinamide mononucleotide supplementation habits.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair discusses the economic issues associated with research using nicotinamide riboside and nicotinamide mononucleotide.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair discusses the current state of research on nicotinamide mononucleotide.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair discusses the stability issues encountered with nicotinamide riboside and nicotinamide mononucleotide.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair discusses the current state of research on the NAD+ boosters nicotinamide riboside and nicotinamide mononucleotide.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes research demonstrating the beneficial effects of resveratrol on the cardiovascular system of monkeys.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes how plant-based compounds activate cellular protective mechanisms in humans.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes the NAD+ salvage pathway and how boosting cellular NAD+ levels may be beneficial in slowing aging.

Posted on November 7th 2019 (7 months)

In this clip, Dr. Rhonda Patrick describes a study in which stem cell-derived retinal cells were used to treat macular degeneration in a human.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair talks about the discovery of genes that can reset the Horvath epigenetic clock.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes how epigenomic modifications can influence how an organism ages, potentially reversing years of age-related damage.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair explains why NAD+ levels decrease with age.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes the links between NAD+, sirtuins, and resveratrol in the aging process.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes the role of NAD+ in the regulation of the body's circadian clock and sirtuin production.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes how sirtuins, caloric restriction, fasting, and the insulin-IGF-1 pathway converge to modulate aging and lifespan.

Posted on November 7th 2019 (7 months)

In this clip, Dr. David Sinclair describes the major breakthroughs in aging research and the unique relationships that develop between researchers and the organisms they study.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Valter Longo describes the origins of the fasting-mimicking diet and explains how it enhances chemotherapeutic treatments.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths describes the current state of research on psychedelic drugs.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Charles Raison describes the complex relationship between inflammation and depression.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths discusses the potential uses, challenges, and risks associated with gaining FDA approval for psilocybin use as a therapeutic treatment.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Valter Longo describes the IGF-1 pathway and explains how defects in the pathway influence disease risk.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths describes the current state of research on long-term meditation and the role psilocybin plays in that research.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths discusses the reorganizational effects that psychedelic experiences have on the brain and their potential use in treating mental disorders.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the sociocultural aspects of hallucinogenic substance use.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths and Dr. Rhonda Patrick discuss the effects of meditation on gene expression.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths discusses similarities in the effects of psilocybin and meditation on the brain and their potential usefulness in treating depression.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Rhonda Patrick describes how sauna use activates the Salvinorin A pathway, potentially ameliorating symptoms of depression and opioid addiction.

Posted on November 5th 2019 (7 months)

In this clip, Dr. Roland Griffiths describes new findings that suggest psilocybin may be useful in managing the symptoms of treatment-resistant depression.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo defines the different fasting modalities, and compares and contrasts the variations of each in duration and degree of restrictiveness.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo explains how certain macronutrients influence the insulin/IGF-1/growth hormone axis to modulate aging in many cell types.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo discusses how the fasting-mimicking diet nourishes patients while still activating some of the same metabolic responses as a water-only fast.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo describes how fasting and the ketogenic diet used together with the standard of care treatment may help treat aggressive cancers.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo explains why clinical trials of the fasting-mimicking diet in combination with standard cancer treatments have been slow to progress.

Posted on September 5th 2019 (9 months)

Dr. Longo describes the promising research that suggests that one's risk for diseases over the next 10 years may be drastically reduced.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo discusses how the fasting-mimicking diet is one of the few dietary interventions that can increase relative lean body mass.

Posted on September 5th 2019 (9 months)

Dr. Longo discusses his work that indicates that the fasting-mimicking diet holds promise for the treatment of autoimmune diseases, particularly multiple sclerosis.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo describes the pivotal role that IGF-1 plays in the proliferation of stem cells and the importance of consuming sufficient protein.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo highlights which biomarkers, both currently available and forthcoming, that he considers relevant when assessing longevity and biological age.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo explains how frequently the fasting-mimicking diet can be practiced and his hope that it may support sustained weight loss.

Posted on September 5th 2019 (9 months)

Dr. Valter Longo discusses his new book "The Longevity Diet" and how his fasting-mimicking diet can treat or prevent several age-related diseases.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison discusses his belief that ancient practices are more likely than modern pharmacology to encourage resilience and stave off depression.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison explains how agents that interact with the immune system may play a subtle and complex role in depression.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison discusses how a pro-inflammatory environment, such as that which occurs with obesity, can contribute to the risk of depression.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison describes the convergence of data that is directing scientists to uncover the connection that exists between inflammation and depression.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison describes the Wild 5 trackable wellness intervention and how it may be incorporated into the treatment of depression.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison discusses how exposure to light during the day and maintaining a dark environment at night, is important in depression management.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison describes how changes in time zones or sleep/wake patterns can be a stressor for individuals with bipolar disorder.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison and Dr. Rhonda Patrick discuss the potential benefits of meditation and running to improve mood.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison describes how the body has evolved to employ some of the same physiological mechanisms in depression and physical illnesses.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison describes strategies that have evolved to offset the risks associated with eating, such as inflammation and the antibiotic effects of hyperthermia.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison describes how whole-body hyperthermia has the potential for real-world clinical efficacy as a tool in the fight against major depression.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison explains that taking non-steroidal anti-inflammatory agents or high dose antioxidants may block some of the benefits of exercise.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison explains the relationship between thermoregulatory dysfunction and how periodic exposure to high heat may aid with treating depression and schizophrenia.

Posted on August 28th 2019 (9 months)

Dr. Charles Raison highlights how ancient practices such as heat exposure, long-distance running and fasting may promote well-being in the modern world.

Posted on August 27th 2019 (9 months)

Dr. Charles Raison discusses how psychedelic substances like psilocybin, which induce transcendent trance-like states may be useful in the treatment of depression.

Posted on July 15th 2019 (11 months)

Dr. Elissa Epel discusses potential concerns about supplementation and describes some of the studies that demonstrate the links between healthy lifestyle behaviors.

Posted on July 15th 2019 (11 months)

Dr. Elissa Epel identifies several biohacks that show promise as strategies to reduce stress and lengthen telomeres.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick describes the effects of endogenous ketones on fat metabolism during a fast.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick provides advice on how to break a fast.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick discusses when electrolyte replenishment might be necessary.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick describes the dual nature of biochemical pathways involved in aging and explains how exercise tips the balance toward its beneficial properties.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick discusses the circumstances under which eating prior to exercise is beneficial versus detrimental.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick describes some of the different types of fasting and identifies the advantages associated with each.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick discusses the pros and cons of consuming black coffee and amino acids during fasting.

Posted on July 15th 2019 (11 months)

Dr. Jari Laukkanen discusses the benefits and risks associated with cold water immersion following sauna use.

Posted on July 15th 2019 (11 months)

Drs. Rhonda Patrick and Jari Laukkanen discuss the benefits of sauna use in terms of cardiorespiratory fitness and mood.

Posted on July 15th 2019 (11 months)

Drs. Rhonda Patrick and Jari Laukkanen discuss the advantages of sauna use post-exercise.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick describes the role that heat shock proteins play in reducing the risk of disease.

Posted on July 15th 2019 (11 months)

Dr. Jari Laukkanen discusses the optimal temperature and amount of time for sauna use to obtain the greatest health benefits.

Posted on July 15th 2019 (11 months)

Dr. Jari Laukkanen describes some of the mechanisms that drive healthy blood pressure among men who use the sauna regularly.

Posted on July 15th 2019 (11 months)

Drs. Rhonda Patrick and Jari Laukkanen discuss findings from a study linking sauna use and lower risk of death from cardiovascular disease.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin describes the liver's functions and proposes that the ketogenic diet does not put any undue stress on the liver.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin discusses several ways in which NAD+ supplementation can benefit mitochondrial health and play a protective role against aging.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin explains how nicotinamide adenine dinucleotide levels diminish with age along with the ongoing research to understand the reasons why.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin describes the emerging field of biomarkers of aging and the diverse strategies, including artificial intellegence, that are being employed.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin discusses the idea that increasing protein levels too high while on a ketogenic diet may have adverse health effects.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin describes how supplementing with exogenous ketone esters may confer some of the beneficial effects of the ketogenic diet.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin explains how a cyclic or the portion-controlled ketogenic diet is linked to improvements in lifespan and memory in mice.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin describes how fasting or a fasting-mimicking diet can influence healthspan and lifespan including discussion of some of the potential mechanisms.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin explains the importance of the insulin signaling pathway in aging and highlights both animal and human research in this area.

Posted on July 15th 2019 (11 months)

Dr. Eric Verdin explains how exercise and nutrition form the cornerstone of strategies to slow aging, but exciting approaches are ahead.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo discusses the longevity-conferring effects of diminishing the pro-aging IGF-1 pathway.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo discusses how autophagy may function in both normal and cancer cells.

Posted on July 15th 2019 (11 months)

Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo discusses the origin of the fasting-mimicking diet and a possible shift from a drug-centered mentality to one which allows the body to heal itself.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes how fasting may reduce the toxicity of chemotherapeutic drugs while also maximizing their impact in the treatment of cancer.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes how fasting promotes the immune system to return to a more youthful profile.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes how the fasting-mimicking diet can be beneficial in the treatment of various diseases, including multiple sclerosis.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo explains how fatty acid usage by cancer cells weakens them and makes them more susceptible to immune system clearance.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes how a fasting-mimicking diet can be used for fat loss while preserving lean muscle mass.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo explains the difference between caloric restriction and periodic fasting and highlights the importance of refeeding after a fast.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo discusses how fasting can play a role in the activation and renewal of stem cells by altering the metabolic profile.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes how a fasting-mimicking diet can reduce markers of inflammation, resetting our biological systems to a more youthful state.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes how prolonged fasting and subsequent refeeding, sends signals to the body to systematically shrink and rebuild organ systems.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo explains the benefits of a prolonged fast.

Posted on July 15th 2019 (11 months)

Dr. Valter Longo describes his approach to fasting and his philosophy that if an eating protocol is too regimented people will abandon it.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes mitophagy, a cellular signal for mitochondrial biogenesis, and a key player in other physiological processes.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the cellular process of autophagy and what factors trigger its activation.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes how mitophagy contributes to the pathophysiology of neurodegenerative disease and how autophagy might mitigate these processes.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes how fasting associated with sickness behavior is critical to surviving infection.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the complex relationship that exists between cancer cells, the immune system, and autophagy.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer discusses changes that occur within cells that signal the need to induce autophagy.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the anti-diabetes and anti-obesity effects of exercise-induced autophagy.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the interplay between protein deacetylation and autophagy.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes how intermittent fasting recapitulates the life-extension benefits of caloric restriction without some of the drawbacks.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer discusses the autophagy-inducing qualities of coffee.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the autophagy-inducing behaviors he practices as part of his healthy lifestyle.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the autophagy-inducing effects of calorie restriction mimetics such as spermidine and resveratrol.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the spectacular biological phenomenon known as autophagy.

Posted on July 15th 2019 (11 months)

Dr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes the beneficial effects of time-restricted feeding in mice in terms of mitochondrial health.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda explains the role of the suprachiasmatic nucleus – the body's master clock – and how it affects metabolism.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes CLOCK's varied response to light and food and how those responses affect metabolism.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes how the body's circadian clocks developed and the role they play in regulating our day-to-day functioning.

Posted on July 12th 2019 (11 months)

Dr. Rhonda Patrick describes how bright light exposure drives cortisol release.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes how time-restricted eating lessens the symptoms of acid reflux in people who practice time-restricted eating.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes some of the challenges associated with studying the effects of shift work and how time-restricted eating might benefit those who work shifts.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda explains the ideas behind MyCircadianClock and how it is helping the research surrounding time-restricted eating.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes the maturation schedule of the body's circadian clocks and makes recommendations about when to start time-restricted eating in children.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes how circadian rhythms influence DNA damage and repair, especially in the setting of time-restricted eating

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda explains the physiological response to food and why eating less often while practicing time-restricted eating might have even greater health benefits.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes his take on what "healthy" means from a circadian perspective and how time-restricted eating plays a part.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes recent research that links melatonin to metabolism and explains how time-restricted eating can capitalize on this link.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes the role fasting plays in maintaining a healthy gut and reducing systemic inflammation.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda discusses the limited data available today regarding dietary supplement usage, exercise, and time-restricted eating.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda quells concerns that toothpaste might start the circadian clock.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes how autophagy, as part of the body's response to time-restricted eating, benefits health on a daily basis.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda describes the state of the science with regard to understanding the beneficial effects of time-restricted eating in humans.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda explains how time-restricted eating realigns the primordial rhythms of our physiology, allowing us to repair and rejuvenate our bodies.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda discusses when to break a fast and describes how time-restricted eating can be a healthy lifestyle behavior for nearly everyone.

Posted on July 12th 2019 (11 months)

Dr. Satchin Panda discusses the controversy surrounding consumption of black coffee or tea while practicing time-restricted eating.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen identifies the defining characteristics of Alzheimer’s disease and enumerates its known subtypes.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen describes the risks associated with APOE4 and identifies strategies for mitigating that risk.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen discusses strategies for identifying factors that contribute to one's risk of developing Alzheimer's disease and describes strategies for mitigating that risk.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen describes the role that zinc status plays in the development of the toxic form of Alzheimer's disease.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen describes his novel dietary protocol, the Ketoflex 12/3, and how it improves cognitive function.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen describes the links between pathogen exposure and Alzheimer's disease.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen describes how sauna use is now being used as a means to reduce the body's overall toxic burden.

Posted on July 12th 2019 (11 months)

Dr. Dale Bredesen discusses the potential brain-health benefits associated with a ketogenic diet.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how studies in rats and humans demonstrate that the brain "replays" events and experiences to facilitate learning.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how sleep impairs the opposing actions of the amygdala and prefrontal cortex to influence mood and mental health.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how sound and smell cues played during learning and subsequent sleep can enhance memory formation and retrieval.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker explains how altering light-dark schedules can improve health outcomes in older adults and babies.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker talks about the importance of identifying early-life windows of vulnerability to prevent or delay age-related cognitive decline.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how napping facilitates and reinforces learning in infants.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how REM sleep facilitates creativity, new ideas, and wisdom.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how sleep deprivation promotes a kind of "viral" loneliness.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the deleterious effects that poor sleep has on the immune system.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the risks associated with sleeping pill use and the benefits of cognitive behavioral therapy as an alternative treatment for sleep problems.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the four essential pillars of sleep.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how sleep deprivation drives a preferential desire for high carbohydrate foods.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker discusses the role that sleep plays in modulating the gut microbiome.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the role that sleep plays in learning and new memory formation.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker posits his theory that dreams are not forgotten; rather, they are merely inaccessible and may influence our wakeful state.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker discusses how anxiety affects sleep and identifies ways to manage that stress to improve sleep.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker explains how sleep and sauna may induce sleep through their short-term pro-inflammatory effects.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the negative effects of blue light exposure on melatonin production and sleep.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker explains how sleep deprivation impairs glucose metabolism, increasing the risk of diabetes and metabolic dysfunction.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the dual risk of carrying the APOE4 allele and having sleep apnea.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the different chronotypes and the risks associated with adopting a sleep pattern that is contrary to our natural type.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the role that sleep plays in modulating the accumulation of amyloid-beta accumulation in the brain.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes critical factors that influence healthy sleep patterns, including the intake of caffeine, alcohol, and other substances.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes how the different stages of sleep influence emotional and cardiovascular health.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker discusses the harmful effects of sleeping pills on learning and memory formation.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker describes the role of temperature in augmenting sleep.

Posted on July 12th 2019 (11 months)

Dr. Matthew Walker explains how altering the timing and duration of daytime light exposure influences sleep.

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson describes how obesity - along with the growth factors estrogen and insulin - affect the risk of breast cancer development and recurrence.

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson discusses how skipping breakfast and eating late into the evening may contribute to worse metabolic health.

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson discusses how simply changing when one eats can have a profound effect on the risk of breast cancer recurrence.

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson describes the advantages of an earlier eating window on inflammation and blood glucose control.

Posted on July 12th 2019 (11 months)

In this clip, Dr. Ruth Patterson discusses the effect that meal frequency has on breast cancer risk.

Posted on July 12th 2019 (11 months)

In this clip, Dr. Ruth Patterson discusses how eating in accordance with the body's natural circadian rhythm may reduce the risk of breast cancer.

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson describes how eating following the body's circadian clock enables the body to focus on repair rather than on digestion.

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson discusses how healthful choices, such as even modest weight loss, can have beneficial effects that reduce the risk of breast cancer and a variety of other diseases

Posted on July 12th 2019 (11 months)

Dr. Ruth Patterson discusses the beneficial effects that time-restricted eating can have on the biomarkers of health - independent of weight loss.

Posted on July 12th 2019 (11 months)

Dr. Patterson explains how a lifestyle approach - an altered eating window - can be an effective way to reduce blood sugar levels.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes how pre-pregnancy parental health impacts offspring.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes the effects of longer sperm telomere length on subsequent generations.

Posted on June 25th 2019 (11 months)

Dr. Rhonda Patrick and Dr. Elissa Epel describe the factors that influence how we respond to diet.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes how even small lifestyle changes can have an effect on telomere length and healthy aging to compress morbidity.

Posted on June 25th 2019 (11 months)

Dr. Rhonda Patrick and Dr. Elissa Epel discuss how obesity affects genes in sperm DNA involved in metabolic health and cognitive function.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel discusses the pros and cons associated with taking dietary supplements to lengthen telomeres.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel discusses how cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel discusses the harmful effects of what she calls a "toxic lifestyle," one that includes the consumption of sugar-sweetened beverages.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes some of the studies that demonstrate the links between healthy lifestyle behaviors like exercise and discusses potential mechanisms.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes the "low hanging fruit" – small, healthy lifestyle behaviors – that can have positive effects on telomere length and lifespan.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel identifies some of the key differences in male and female biology and how they influence telomere length and aging.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel gives a brief overview of telomeres and the enzyme telomerase and explains how they impact health and lifespan.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel discusses the importance of having an optimal ratio of telomerase to reduce the risk of chronic diseases and cancer.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel explains how aging syndromes can be passed to offspring via epigenetic mechanisms.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes how Mendelian randomization techniques provide insights into the dual nature of telomeres, as both a cause and a sign of aging.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes the exposome – the totality of non-genetic exposures a person experiences during a lifetime – and explains how it affects telomeres.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes how toxic stress modulates telomere length.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes the beneficial effects of education on telomere length in the babies of low-income women.

Posted on June 25th 2019 (11 months)

Dr. Elissa Epel describes the non-linear effects of exercise on telomere length.