Aliquot #91: How blood-brain barrier dysfunction fuels Alzheimer's disease
Aliquot #91: How blood-brain barrier dysfunction fuels Alzheimer's disease
The blood-brain barrier is a collection of membranes that separate the central nervous system from the circulatory system. It permits the passage of nutrients and other beneficial molecules from the bloodstream into the brain while excluding harmful ones. Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.
Get these episodes in a convenient podcast format.
Aliquot episodes make great companion listening for a long drive. You can find these special members-only episodes alongside live recorded Q&As on The Aliquot, our official premium FoundMyFitness podcast.
The blood-brain barrier is a collection of membranes that separate the central nervous system from the circulatory system. It permits the passage of nutrients and other beneficial molecules from the bloodstream into the brain while excluding harmful ones. Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.
In this Aliquot, Dr. Axel Montagne and I discuss factors that weaken the blood-brain barrier.
-
The impact of a compromised blood-brain barrier
-
The Interplay of APOE4 and Cyclophilin A
-
Why APOE4 compromises the blood-brain barrier
-
Is there already a drug that might reduce the damage?
-
Implications for the glymphatic system and toxin clearance
-
How faulty glucose transport in the brain plays a role in Alzheimer's
-
Why low omega-3 may impair glucose transporter function
-
What's the role of hypertension in dementia?
-
Lifestyle approaches to blood pressure and dementia
Get email updates with the latest curated healthspan research
Support our work
Every other week premium members receive a special edition newsletter that summarizes all of the latest healthspan research.
Recent Aliquot Episodes
Aliquot #117: The Science of Lactate in Brain Performance
Lactate often gets a bad rap due to its close association with lactic acid. But lactate plays a distinctly different and often-underappreciated role...
Aliquot #116: Testosterone Optimization Strategies for Men
Testosterone is a steroid hormone produced primarily in the testes in males and in smaller amounts in the ovaries in females. It's crucial...
Aliquot #115: A Lifestyle Guide for Mitochondrial Optimization
Mitochondrial health and overall health are intrinsically linked. Identifying ways to boost mitochondrial biogenesis...
Aliquot #114: Supplements & Diet Strategies to Boost Mitochondrial Function
Mitochondria are best known for their energy-producing roles, but they also help regulate cellular metabolism, signaling, and apoptosis...
Aliquot #113: Is resistance training a type of aerobic exercise?
Aerobic exercise and resistance training are essential for optimal health. However, finding the time to do both can be challenging...