Metformin blunts exercise-induced gains in muscle, strength, and aerobic fitness | Rhonda Patrick
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Several randomized controlled trials have suggested that metformin blunts some of the positive effects of aerobic exercise and strength training. Healthy adults taking metformin exhibited 50 percent less improvement in cardiorespiratory fitness following an exercise program. Other research indicates that metformin inhibits the exercise-induced improvements in mitochondrial respiration and limits gains in lean body mass. In this clip, Dr. Rhonda Patrick describes the many open questions that remain regarding the interaction between metformin and exercise at the molecular level.
Important for the endocrine enhancing properties of exercise. Exerkines are exercise-induced hormonal-like factors which mediate the systemic benefits of exercise through autocrine, paracrine, and/or endocrine properties.[1]
- ^ Helge, Jørn Wulff; Moritz, Thomas; Morville, Thomas; Clemmensen, Christoffer; Dela, Flemming (2020). Plasma Metabolome Profiling Of Resistance Exercise And Endurance Exercise In Humans Cell Reports 33, 13.
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