Time-restricted eating may help the symptoms of gastroesophageal reflux disease (GERD)
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Small pumps in the stomach produce acid to digest food. These pumps function on a circadian schedule. Acid reflux, or heartburn, is a painful digestive disorder in which stomach acid flows into the esophagus. Many people report having less reflux when adhering to a time-restricted eating pattern. In this clip, Dr. Satchin Panda describes how time-restricted eating lessens the symptoms of acid reflux in people who practice time-restricted eating.
- Satchin: So I think on a daily basis, like for example on a daily basis what would healthy, another definition of healthiness while going to be bed at night is not to have this acid reflux or heartburn. Which is essentially a gut sodium...sorry, the proton pump working differently. And what we find in mouse studies is this expression of the level of this proton pump goes down on the time-restricted eating. So this is one example where many of our myCircadianClock users reported saying, "Oh, well, you know, the first benefit we found is our acid reflux has gone down, we don't get that much heartburn." And then we got curious, we went back to what are the targets of all the acid reflux drugs, and we found this proton pump. And interestingly this proton pump expression goes down in mouse gut.
- Rhonda: That's awesome. That is so awesome.
- Satchin: So this is another example where we would never ask about...we don't have even the means to ask what is acid reflux and heartburn in a mouse, but we have a means to actually get this response from users and go back and ask the mechanism in a mouse.
The body’s 24-hour cycles of biological, hormonal, and behavioral patterns. Circadian rhythms modulate a wide array of physiological processes, including the body’s production of hormones that regulate sleep, hunger, metabolism, and others, ultimately influencing body weight, performance, and susceptibility to disease. As much as 80 percent of gene expression in mammals is under circadian control, including genes in the brain, liver, and muscle.[1] Consequently, circadian rhythmicity may have profound implications for human healthspan.
- ^ Dkhissi-Benyahya, Ouria; Chang, Max; Mure, Ludovic S; Benegiamo, Giorgia; Panda, Satchidananda; Le, Hiep D., et al. (2018). Diurnal Transcriptome Atlas Of A Primate Across Major Neural And Peripheral Tissues Science 359, 6381.
A digestive disorder, also known as acid reflux. GERD is characterized by burning pain in the upper abdomen, chest, and back. Treatment of GERD usually focuses on dietary and lifestyle modifications and pharmaceutical measures to reduce stomach acid production, and includes proton pump inhibitors, histamine blockers, and over-the-counter antacids.
A digestive disorder in which acid in the stomach flows into the esophagus. Reflux can damage the esophagus over time, leading to structural and functional changes. Barrett’s esophagus is a type of precancerous condition related to reflux.
Restricting the timing of food intake to certain hours of the day (typically within an 8- to 12-hour time window that begins with the first food or non-water drink) without an overt attempt to reduce caloric intake. TRE is a type of intermittent fasting. It may trigger some beneficial health effects, such as reduced fat mass, increased lean muscle mass, reduced inflammation, improved heart function with age, increased mitochondrial volume, ketone body production, improved repair processes, and aerobic endurance improvements. Some of these effects still need to be replicated in human trials.
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Circadian rhythm News
- High-intensity exercise in the evening may be associated with greater reductions of the hunger stimulating hormones
- Time-restricted eating prevented obesity and metabolic syndrome in mice with mutations in genes regulating the circadian clocks.
- Caffeine that was given to people 3 hours before normal bedtime caused a 40-minute shift in the body's internal clock.
- After exposure to daytime bright light (6.5 hours), evening use of a tablet for two hours did not affect sleep in healthy young students.
- Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. - PubMed - NCBI
