Episodes

Resveratrol’s impact on the cardiovascular system | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair identifies some of the practical considerations of resveratrol supplementation and discusses his personal use of the compound.

Resveratrol improves aortic stiffness (in rhesus monkeys) | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes research demonstrating the beneficial effects of resveratrol on the cardiovascular system of monkeys.

How stressed plants communicate to our genes (to our benefit) | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes how plant-based compounds activate cellular protective mechanisms in humans.

NAD+ boosters: NR, NMN, and how they affect sirtuins | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes the NAD+ salvage pathway and how boosting cellular NAD+ levels may be beneficial in slowing aging.

Induced pluripotent stem cells used to treat macular degeneration | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. Rhonda Patrick describes a study in which stem cell-derived retinal cells were used to treat macular degeneration in a human.

Discovery of genes that reset the Horvath Clock | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair talks about the discovery of genes that can reset the Horvath epigenetic clock.

Genetic strategies for reversing epigenetic age (Horvath Clock) | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes how epigenomic modifications can influence how an organism ages, potentially reversing years of age-related damage.

Why we lose NAD+ in aging [DNA repair & inflammation] | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair explains why NAD+ levels decrease with age.

NAD+ and resveratrol levels affect the aging process | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes the links between NAD+, sirtuins, and resveratrol in the aging process.

How NAD+ resets the circadian clock and regulates sirtuins | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes the role of NAD+ in the regulation of the body's circadian clock and sirtuin production.

The link between sirtuins, calorie restriction, fasting, and the insulin pathway | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes how sirtuins, caloric restriction, fasting, and the insulin-IGF-1 pathway converge to modulate aging and lifespan.

History and discovery of longevity genes | David Sinclair

Posted on November 7th 2019 (over 4 years)

In this clip, Dr. David Sinclair describes the major breakthroughs in aging research and the unique relationships that develop between researchers and the organisms they study.

Fasting diet may make cancer treatment more effective | Valter Longo

Posted on November 5th 2019 (over 4 years)

In this clip, Dr. Valter Longo describes the origins of the fasting-mimicking diet and explains how it enhances chemotherapeutic treatments.

Therapeutic effects of psilocybin in treatment of anxiety and depression | Roland Griffiths

Posted on November 5th 2019 (over 4 years)

In this clip, Dr. Roland Griffiths describes the current state of research on psychedelic drugs.

Immune stimulation may treat depression via cytokines that boost neurotrophic factors | Charles Raison

Posted on November 5th 2019 (over 4 years)

In this clip, Dr. Charles Raison describes the complex relationship between inflammation and depression.

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