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“This is confirmed in a toxicology study published in 2011 in Environmental Health Perspectives, which examined more than four hundred and fifty commercially available plastic products used to contain foodstuffs.4,5 The investigators found that almost all of the products sampled “leached chemicals having reliably detectable EA [estrogenic activity], including those advertised as BPA free. In some cases, BPA-free products released chemicals having more EA than BPA-containing products.”5 As these authors note, chemicals with estrogenic activity can cause numerous adverse health effects in “fetal and juvenile mammals,” “especially at low (picomolar to nanomolar) doses.”5”
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BPA-free always makes me question what has replaced it. BPA-x? Does anyone know about the safety of sous vide silicone bag?
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Original Abstract from Nature Genetics:
https://www.nature.com/articles/s41588-018-0303-9
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
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This article starts here: https://www.medscape.com/viewarticle/902985
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Related citation of interest: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892413/ Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan.
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Previous studies showed: polipoprotein E4 binds DNA with high affinity and that its binding sites include 1700 promoter regions that include genes associated with neurotrophins, programmed cell death, synaptic function, sirtuins and aging, and insulin resistance, all processes that have been implicated in Alzheimer’s disease pathogenesis. http://www.jneurosci.org/content/36/3/685.long
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Related to the following episodes of foundmyfitness:
Jed Fahey, Sc.D. on Isothiocyanates, the Nrf2 Pathway, Moringa & Sulforaphane Supplementation - Dr. Jed W. Fahey is a nutritional biochemist with deep experience researching isothiocyanates like sulforaphane.
How To Increase Sulforaphane in Broccoli Sprouts by ~3.5-fold - This is a video on how to plausibly increase the sulforaphane created from the glucoraphanin in your broccoli sprouts by up to 3.5-fold.
Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More - This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.
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Also see the following and references therein for food substances reported to enhance the Function and Development of Astrocytes.
https://biofoundations.org/enhance-the-function-and-development-of-astrocytes-with-mustard-seedsoil/
Awesome interview and information. Thank you, Rhonda!