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    But do we really have a clear definition of ageing that encompasses its full metabolic scope? Without that, it seems a bit premature to settle for one on-off-switch. Surely, the unwinding of chromatin and the role of histone proteins etc. is just one aspect of this complex issue. For example, every few months when you look up what ’s new with a global epigenetic regulator like FOXO3, someone has described another effect. “An on-off switch” is exciting…… but it’s one switch!