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    NMN is the direct precursor to NAD+. Therefore it converts into NAD+ when you take it. Cold and hot exposure puts your body in a good stressed state - hormesis. It makes you more resilient.

    NMN should be stored cold. Most brands don’t do cold storage, which will inhibit sirtuin activity. Check out verso supplement - they do cold storage. Website: ver.so

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      Question? Dr. David Sinclair noted that NMN was the key to slow the aging process down, You say NAD, he said cold is good and your paper said sauna (hot) . As a WFPB/CNS I am confused - can you help out? Steven J. Lucks CNS luckssj@msn.com.

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        I’m looking for a reasonably affordable DNA testing service with the broadest, most comprehensive selection of genes w/out conspicuous sacrifices to accuracy.

        Where might I go to make a comparison that takes this merit into account?

        Are there any contenders that rise above the fray?

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          Here is a useful resource that I just found for anyone else sharing my curiosity & obsession! https://www.snpedia.com/index.php/Testing

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          Interesting video, thanks for the work involved in distilling it down. There has been a lot of work on the benefits of oral 500 mg niacinamide on skin cancer reduction, specifically those prone to precancerous actinic keratosis (basically anyone with fair skin). You never mentioned any relationship there, but did say that niacinamide mono and niaciniamide RNA break down into niacinamide when taken orally. What about just taking 500-1000mg niacinamide daily/orally? Its cheap, well tolerated (maybe skin flushing/reddening in some), with benefits for both cardiovascular/aging and skin improvement? Especially if taken with resveratol?

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            Any role in all of this for Apocynin?

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              Super-interesting information, albiet sort of a tease. If NAD+ has such a profound, ubiquitous biological importance it “seems” like there would have been many human studies done by now to try and quantify the benefits/risks from the various potential mechanisms (e.g., exercise, supplements, fasting). When I hit the lottery, I’ll fund a massive study lead by Dr. Patrick. Thank you very much for your work.

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                What are your thoughts on Nicotine competing with NAD+ in cells and thereby reducing SIRT1? Could this be one of the causes for reduced lifespan in smokers? If so, would that also affect lifespan for people smoking e-cigarettes?

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                  I’m also concerned after listening to Sinclair that sourcing non-degraded NMN is not practical yet. He basically comes out and says people are likely getting degraded products, no matter how expensive.

                  Looking into things I found that there is another NAD+ precurser as indicated here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398323/

                  I wonder why this has not entered the discussion. Something we are missing?

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                    That’s only because most brands don’t do cold storage or process it properly. I literally searched for a year to find a company with GMP and FDA approved processing and does cold storage. Their website is ver.so

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                    After listening to Sinclair, I’m a little concerned about my sourcing for NMN. If it hasn’t been processed, stored and shipped properly it not only could be useless, but dangerous? DS stated that when NMN goes bad it can actually shut off sirtuins? That is scary!

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                      Nuchido claims that their product, Nuchido TIME+, boosts NAD+ four times more than any other product. https://nuchido.com/products/nuchido-time Their evidence is here: https://nuchido.com/pages/science Can their claims be valid? Please delete my comment if it is your policy not to speak for or against any commercial product.

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                        This article “A Reduced Form of Nicotinamide Riboside Defines a New Path for NAD+ Biosynthesis and Acts as an Orally Bioavailable NAD+ Precursor,” https://www.sciencedirect.com/science/article/pii/S2212877819309160 says that “NRH acts as a more potent and faster NAD+ precursor than NR in mammalian cells and tissues.” Would love to hear your thoughts on it.

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                          Can NR or NMN be absorbed into the bloodstream sublingually? If so, then is that a pathway by which either could be converted into NAD+ without the limiting effect of the liver feedback mechanism?