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to the editor: in the recent work of Bielohuby et al. (1) published in this journal, the authors discussed the hypothesis that the restriction of carbohydrates, substituted by the high consumption of fats, induces a state of glucose intolerance and insulin resistance in rats, which was demonstrated through diverse methodologies, including the hyperinsulinemic euglycemic clamps. It was further shown that these effects are independent of the visceral adipose mass and caloric consumption.

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    Pmiguel. Excellent content. Thankyou. I on the have followed a ketogenic diet for the past 3 years. I test ketones regularly out of interest, I do not aim at raising ketones, I find following a real food diet, limiting white carbs keeps me in the low nutritional ketosis range approx 0.5 to 0.8mmol quite easily. Sleep effects it, type of exercise effects it. High intensity resistance training or metabolic conditioning circuits knock me out of ketosis, to drop back in later in the day, steady state endurance for an hour will drop me back in if I am out after a cheat meal.

    Eating a sugary cake will make me lie down and be lazy for a couple of hours after, however if I have new potatoes in a meal it has no effect.

    I started the diet 3 years ago, lost 30lbs in 2 months. Whilst reducing exercise incidently.

    I still eat the same way (I am a monotonous creature of habit with meals) and in the following years my weight has regained 20lbs. However my fat percentage has not increased. It is currently 9.7% via dexa. Interestingly my muscle mass has been increasing from when my bodyweight hit its lowest %. I practice bodyweight callisthenics each day as the stimulus. For me, a ketogenic diet has been excellent.

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      Magonrag you are welcome. I’ve followed a ketogenic diet for about 5.5 years. Yes, I’ve noticed that my BHB levels drop after a powerlifting workout. I used to jog, but haven’t for many years. So its interesting to me that it might have a positive effect on ketones. I hadn’t really intended to stay on a KD this long, but it suits me.

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      Discussed in another thread, but this letter to the editor politely (but completely) refutes “Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets” link: https://doi.org/10.1152/ajpendo.00208.2013

      which, I think, is often the source of the “KD leads to T2D” meme. The meme seems absurd given Virta Health’s success in reversing T2D. But absurdity is no bar to meme propagation…