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    Gene therapy has seen more than 20 years of experiments but research has been dogged by a series of disappointments and safety concerns.

    Some of those safety concerns may be, in part, resolved by systems like CRISPR. One of the problems with many gene therapy techniques is that they can drop the gene somewhat indiscriminately into the genome… and if that turns out to be in the middle of a gene thats useful for preventing the cell from cancerous oh well. That’s what is exciting about technologies that make it easier to put the gene exactly where they want it (like CRISPR).