Granzyme B is the toxic chemical that is released and is produced by our different types of T cells, when they are killing foreign invaders including bacteria, viruses, and cancer cells. Unfortunately the granzyme B that they release when they kill is toxic to our own cells and collagen. Granzyme B can generate autoantigens that can cause the immune cells to recognize their own cells as “foreign,” and this can lead to the development of autoimmune diseases like lupus.
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Can some please explain how this news would apply to someone with discoid Lupus? aka DLE…
Granzyme B is the toxic chemical that is released and is produced by our different types of T cells, when they are killing foreign invaders including bacteria, viruses, and cancer cells. Unfortunately the granzyme B that they release when they kill is toxic to our own cells and collagen. Granzyme B can generate autoantigens that can cause the immune cells to recognize their own cells as “foreign,” and this can lead to the development of autoimmune diseases like lupus.
http://onlinelibrary.wiley.com/doi/10.1111/acel.12298/abstract