1. 3

Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury, characterized by rapid breathing, shortness of breath, and a low blood oxygen level. It occurs in as many as 17 percent of all COVID-19 cases and can lead to respiratory failure and death. Findings presented in a recent review suggest that extracellular superoxide dismutase (EcSOD), a potent antioxidant enzyme produced by the muscles during exercise, can reduce the risk of developing ARDS.

A critical feature of the pathogenesis of ARDS is an excessive immune response that leads to increased production of reactive oxygen species and pro-inflammatory mediators in the lungs. Evidence indicates that EcSOD is highly expressed in lung tissues, where it inhibits many of the pathological features of ARDS and acts as a scavenger of superoxide. Loss of EcSOD activity in mice markedly increases risk of death due to ARDS, however.

An abundance of evidence demonstrates that even a single session of exercise can boost EcSOD production in muscles. Taken together, these findings suggest that exercise could provide protection against ARDS by upregulating EcSOD production.

  1. You must first login , or register before you can comment.

    Markdown formatting available

This news story was included in a recent science digest.

The science digest is a special email we send out just twice per month to members of our premium community. It covers in-depth science on familiar FoundMyFitness related topics.

If you're interested in trying out a few issues for free, enter your email below or click here to learn more about the benefits of premium membership here.

Verifying email address...