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    What is the genetic mutation that some people have that should stay away from dietary cholesterol? Have they found it to be true or is it still under investigation?

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      Interesting that Dr.Krauss doesn’t mention Niacin (nicotinic acid) in the statin talk. Yes, statins can lower total LDL. Maybe a higher percent of the large LDL and very low if any percent of VLDL or small particles. Studies show Niacin rather than statins have shown to raise HDL the main particle that carries LDL and lowers LPa LDL particles out of the body. Has he studied niacin? interested in his comments. Too bad that the flawed HP2S Thrive study didn’t start with Niacin first and add statins to the arms that need more reduction in the large LDL particles. Should be a episode in the show “American Greed”….

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        Excellent and very helpful podcast. As a cardiac patient, I’ll be requesting the detailed lipid profile, which to date my cardiologist and family physician have not ordered. I went on a near vegan diet 3 years ago after discovering I had heart disease, and since then have ordered extra tests on my own. Among other things I’ve established that I can keep LDL under 70 mg/dL without statins. All my lipid markers (except HDL) fell dramatically and quickly when I went on a quality plant based diet. I’ve been intending to do more testing with slight dietary variations in diet (e.g no fruit juice vs the 4 ounces per day I currently consume, and variations in alcohol, fat, and protein intake) and this podcast has given me the incentive to do a better job correlating my blood markers with diet. My cardiologist never brings up lifestyle and has never ordered a detailed particle size test even after me having asked about the test.

        Dr. Krauss discussed the lack of data relating diet and heart disease, so I must assume he discounts the value of observational and clinical studies such as the China Study, Blue Zones, and work done by Dr. Esselstyn with cardiac patients. Would have been interesting to get his take on the non-RCT data, assuming he’s taken a close look.

        And, yes, simple carbs seem to be at the center of a lot of negative health outcomes affecting not only heart disease, but cancer (via increased glucose/insulin), diabetes, mental integrity, and overall longevity.