Skeletal muscle growth early in life is ‘remembered’ by the genes in the muscle, helping them to grow larger later in life.
The study found that genes in skeletal muscle have less DNA epigenetic modifications in response to exercise and throughout periods of inactivity (ie. injury). This allows the muscle to grow even bigger following exercise again later.
This study has many implications but one interesting implication is that if you lose muscle you’re epigenetically primed to get it back.