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Exogenous NAD+ source to combat mitochondrial aging? A single dose (1X) of nicotinamide riboside and pterostilbene increased plasma NAD+ levels by 40% and a double dose (2X) by 90% after 4 weeks (compared to placebo). NAD+ is a cofactor for many metabolic enzymes and becomes depleted across various tissues as we age. This causes the mitochondria to suffer and mitochondrial decay is also thought to also be a key driver of aging. Three other blood biomarkers also showed differences that reached statistical significance. First, diastolic blood pressure was significantly reduced at day 60 in the NRPT 1X group. Second, the liver enzyme ALT showed a significant decrease in the NRPT 1X group at both day 30 and day 60. Third, a small increase in total and LDL cholesterol was observed in the NRPT 1X group at day 60 and larger increases in the NRPT 2X groups.

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    Could someone explain the difference between taking a supplement like Thorne Niagen vs Niacin? Does taking B3/Niacin offer the similar health benefits?

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      Hi, I’m very excited to try this supplement but found this study about NAD+ helping to grow brain tumors https://siteman.wustl.edu/pathway-linked-slower-aging-also-fuels-brain-cancer/ and paused. What do you think about that? Is it a valid concern and are benefits of NAD+ outweigh potential risks? Thanks!

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        Hi Rhonda I’ve purchased Thorne Research Nicotinamide Riboside - each capsule is 125mg and it says on the packaging to take one a day or as directed by your physician. I train 3-4 times a week, non smoker, healthy eater - mostly - 5ft 2 and 50kg. Would you say 1 cap a day is enough or should I be taking more in order for this to have an impact? Thankyou.

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          This study found a dose of 250 mg was shown to increase NAD+ levels by 50% in participants…a dose of 500 mg raised NAD+ levels by 90% after 4 weeks.

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          After reading up on nicotinamide riboside and pterostilbene, I’m not sure if pterostilbene replaces resveratrol entirely or should be taken in addition too? is it one or the other or are there benefits to taking both? This would be along with pterostilbene.

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            Since they’re both stilbenoids, it’s probably a little bit redundant to take both.

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            Definitely very interesting. Does this mean that taking this combo (which is the Basis product by Elysium) a good way to try to stave off aging?

            Is it something that is worth taking if you are younger than the population in the trial (men and women ages 60 - 80)

            Edit: also, how do these effects compare to a combo with regular (cheap and not patented) B3?

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              My interest is definitely piqued. The animal evidence is exciting too. That said, I do worry about some of the changes they observed in cholesterol (although I think that was due to pterostilbene). It might not be that worthy of concern (there’s more to heart disease than just total LDL), but, in general, I’d still like to see more evidence.

              I realize that this doesn’t answer your questions directly. They’re good ones, but I don’t have all of the answers.

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                Anyone considering buying from Elysium should think twice. Here is why: https://www.right-of-assembly.org/single-post/2017/08/16/Why-I-Feel-Suckered-by-Elysium-Health

                I personally went with Thorne (Tru Niagen carries a 25% import duty where I live or I would have opted for those).

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                  That’s good to hear the animal evidence looks exciting, and hopefully the cholesterol observations aren’t an issue.

                  Elysium Health seem to be on the right path. (Still always skeptical of a company funding/doing research on their own products)

                  But they were very responsive on twitter relating to this study and their desire to look into taking human biopsies in future clinical trials to answer if NAD concentrations actually increase in the mitochondria vs circulating in the blood/tissues.

                  Definitely an area to keep on my radar.

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                    Regarding the funding issue: that’s true, but this issue is definitely mitigated by the impact factor of the journal IMO. A Nature paper is pretty top shelf.

                    They’re definitely doing Twitter right… I think the Twitter thread to which you’re referring shows a desire to talk to the actual science. I was impressed, anyway.