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Corticosteroids have been used since the 50s as anti-inflammatory and immunosuppressive drugs for the treatment of several pathologies such as asthma, allergy, rheumatoid arthritis, and dermatological disorders. […]
Neuroimaging studies in patients taking corticosteroids have related a decrease of hippocampal volume and brain atrophy due to a reduced blood flow in areas of the brain responsible for cognitive functions.
The cognitive effects of corticosteroids appear to be occasional and include disorders, which consist of dementia or delirium. The type of deficiency coincides with the dysfunction at hippocampal level, which is rich in glucocorticoid receptors. […]
The use of corticosteroids is strongly associated to the development of psychiatric/neurological side effects.
I wonder if this applies to nasal spray as well, as I know there is less systemic absorption.