I do plan on diving in an doing short videos on specific SNPs, particularly ones related to fat metabolism since low-carb, high-fat and ketogenic diets have become popular. The PPAR-alpha SNP is one that is most concerning when it comes to ketogenic diets since that gene is essential for the process of ketogenesis. It is good that you measured a variety of blood biomarkers since that is really the only way to test whether a diet works for you.

What you’re saying might suggest that a ketogenic diet may not work for you. At least that’s one way to interpret it. (Note: I don’t mean that as medical advice!)

With respect to PPAR-alpha, other factors that can activate are polyunsaturated fatty acids particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are the fatty acids abundant in fish oil. DHA and EPA have been shown to be agonists for PPAR-genes. PPAR-alpha is under circadian regulation, so time-restricted eating may be even more important. If you really want to try a monounsaturated and polyunsaturated fat-based ketogenic diet see my comment to @brywatson. Of course, you would have to measure your blood biomarkers again to monitor how the diet affects those markers of health status. It would be appropriate to monitor these under the trained guidance of a physician.