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A ketone body called beta-hydroxybutyrate that is produced during fasting or a ketogenic diet activates a stem cell factor in the vascular system which protects against DNA damage-induced senescence and vascular aging (mouse study).

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    Is there any indication what minimum level of beta-hydroxybutyrate would be necessary for this protection. That is could this be achieved by just taking a couple of grams of an exongenous beta-hydroxybutyrate salt.

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      @woody42, not really. My take was >2nM might reach the therapeutic range. But that is pure speculation on my part. I’m doubting most people can get to >2nM just taking a couple of grams of exogenous BHB-salt. But it would depend on what your diet, etc. were like otherwise.

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      From the paper: “Cellular quiescence is a crucial process for maintaining the stemness of embryonic stem cells (ESCs) through inducing autophagy. We did not show sufficient results to prove β-HB induces autophagy and autophagy-dependent cellular quiescence (An et al., 2014, García-Prat et al., 2016). However, we predict that β-HB can induce autophagy in vascular cells, as well as ESCs, based on our observations of AMPK activation and mTOR inhibition by Oct4 upregulation after treating with β-HB in vascular cells. ”

      @rhonda – is this enough to make you consider a ketogenic diet? Since I started ~8 hour TRE, I have no difficulty maintaining >2mM BHB fasted most mornings of the week.

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        I’m considering experimenting a modified ketogenic-ish diet with an emphasis on salmon, avocado, olive oil, nuts…as long as I can eat a lot of leafy greens and some blueberries.

        I also seem to have no problem getting high levels of BHB with a 16-hour fast.

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          What concentration of blood BHB do you get after a 16-hour fast?

          Leafy greens don’t seem to be an issue for me. I’m eating 2 large salads a day sometimes. I put lots of a salad dressing I make myself on them–just “O-live” olive oil (~80%), Braggs ACV (~20%), sweetened with some raspberry stevia.