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Time-restricted eating (TRE), a ketogenic diet, and exercise improved cognitive function and markers of metabolism including triglycerides, VLDL, and HbA1c in a 71-year-old woman with ApoE4 that has mild Alzheimer’s disease and metabolic syndrome (case study).
This is an interesting proof of principle study showing that implementing a nutrition protocol purposed at raising plasma ketones through fasting (TRE) a ketogenic diet and physical exercises can compensate for insulin resistance and the ApoE4 gene in a mild Alzheimer’s patient experiencing cognitive impairment.
The APOE4 gene is the largest risk factor for Alzheimer’s disease besides age itself.
To learn more check out this episode highlight of Dr. Dale Bredesen talking about time-restricted eating and a ketogenic diet in the context of Alzheimer’s disease in people with and without ApoE4.
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I wish people would define what they mean by keto. Because I recall one of the scientists on your podcast described a study on mice that showed that did not have good health outcomes (I believe the mice died?) when they were given access to high fat food because they ate too much. It was only the low calorie high fat diet that showed positive results.
what about the effects of saturated fats on a ketogenic diet and having the apoe 4 gene?