Older men and women that supplemented 500 mg of resveratrol a day combined with aerobic and resistance exercise for 12 weeks improved mitochondrial density and muscle fatigue and had a 45.3% increase in muscle fiber area and a 20% increase in total muscle fiber myonuclei compared to men in the placebo group.

In addition, participants that were treated with resveratrol had an 8% increase in knee extensor muscle peak torque, 14% increase in average peak torque, and 14% increase in power after training, whereas exercise did not increase these parameters in the placebo-treated older subjects.