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Clearing away senescent cells in the brain using senolytic drugs prevented brain degeneration in mice genetically prone to it. The diseased animals were able to form memories, eliminated signs of inflammation, and did not develop tangles in the brain.
I have a great episode with an expert on cellular senescence. I recommend checking out the recently revamped show notes even if you don’t have the time for the full episode. https://www.foundmyfitness.com/episodes/judy-campisi