Serotonin 5-HT2A receptor activation (molecular target of classical psychedelics) suppresses TNF-alpha-induced inflammation with extraordinary potency

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Serotonin 5-HT2A receptor activation (molecular target of classical psychedelics) suppresses TNF-alpha-induced inflammation with extraordinary potency brain immune system inflammation psychedelic ncbi.nlm.nih.gov
submitted about 6 years ago by dan

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We have now discovered that activation of 5-HT(2A) receptors in primary aortic smooth muscle cells provides a previously unknown and extremely potent inhibition of tumor necrosis factor (TNF)-alpha-mediated inflammation. […] With the exception of a few natural toxins, no current drugs or small molecule therapeutics demonstrate a comparable potency for any physiological effect

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